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Top 10 Best Medicinal Mushroom Supplements to Buy in 2021

How well do you know the mushrooms you add when cooking? The majority of them are edible. However, medicinal mushrooms are a different story.

Today, you will learn about mushroom supplements and their health benefits, history, and side effects.

Do not worry; they are not harmful so long you speak with your doctor beforehand. What you need to know is that a lot of us ignore this ingredient.

You have no idea how helpful these mushrooms are for your immune and cognitive systems. How about we find out everything once and for all?

The list you see below is made after a long deliberation with plenty of research of our own.

What Do You Know About Mushroom Supplements?

The mushroom supplements are not chunks of mushrooms dried and cut out to serve in a container. They are nothing like you are used to seeing in the supermarkets.

Real mushrooms may come in mushroom powder, mushroom extracts, or mushroom capsules. We recognize this process and term as adaptogenic mushrooms.

But the concrete question is why you should have them. Well, we will address the detailed health benefits in the sections below.

But the short version is, mushroom supplements boost the immune system, reduce inflammation, and potentially diminishes the risks of cancer or tumor.

I hope this gets your attention because we will dive right into the history before taking off for the best medicinal mushroom supplements.

How Old is the History of Medicinal Mushrooms?

We will not bore you with the deep talks about how one chanced upon such mushrooms. There are thousands of years old worth of references, which you cannot finish reading in a day.


The years are not specific, but it was around 100 BCE when the benefits of medicinal mushrooms emerged in China. There were no doctors then, but the Chinese who practiced medicine brought forth the health benefits.

These beneficial facts are still rooted in the ancient research to produce some mushroom supplements.

The traditional medicine practitioners claimed certain mushrooms to fight against respiratory diseases, cancer, and so on.


Scientists found references written in hieroglyphics where Egyptians believed medicinal mushrooms were a source of immortality.

It sounds ludicrous now but, imagine that a fungus was able to treat Pharaoh from his deathbed. Thus, began the use of medicinal mushrooms for longevity and the healthy body of the nobles.

Rome and Greece

These two historical lands were no different. It was well after the Chinese and Egyptian reigns and falls.

In this era, there was much evidence showing how medicinal mushroom extracts benefited people. First, the well-known Greek minds, like Dioscorides, recorded such benefits.

Next, when the Roman Empire slowly began to establish, wise men like Pliny and Seneca also discovered ways to use medicinal mushrooms.

Modern Discovery

We were a little late to the party, but the year- 1928 will forever remain notable in the western world.

The Scottish physician and microbiologist Alexander Fleming discovered the first antibiotic substance, penicillin. It was so effective that almost 200 million lives were saved, and the count still goes up.

And how did he discover the substance? Of course, he used fungus, aka mushroom extract.

Since then, the world has learned more; innovative technologies have replaced manual research. Therefore, scientists continue to study non-medicinal or medicinal mushrooms further, including psilocybin substances.

You never know when the next revolutionary breakthrough might strike, but it was Fleming who initially opened our minds.

10 Best Mushroom Supplements

It is time to find out the best mushroom supplements and their health benefits individually. Are you ready?

Onnit Shroom Tech SPORT


Our first choice is the Onnit Shroom Tech SPORT because its product underwent a clinical trial. It is one of the best mushroom supplements popular among athletes and those who work out.

The critical ingredient is the cordyceps mushroom extract, which promotes your energy level upon daily intake. Other influential elements support this boost.

Tech Sport medicinal mushroom supplements will allow you to push forward in high-intensity training programs. Whatever activity you are fond of, let the lack of boosting capacity not be an issue anymore.

Of course, never forget to ask your doctor before consuming, especially if you take other medications.

Each capsule contains cordyceps mushroom extract (1.2 g); adaptogen blend of astragalus, green tea, Rhodiola root, ashwagandha root (930 mg); vitamin B12 (750 mcg); chromium (200 mcg); dextrin, mineralized red algae, etc.

Onnit Tech Sport suggests four mushroom capsules consumption about 45 minutes before exercise. It can be before any competition or strength-support as well.

Four Sigmatic


With Four Sigmatic, you can have a variety of medicinal mushroom supplement choices. This is why the brand has obtained media sensation. The initial reason is the high-grade items.

There are three classifications to select from. The Think category involves lion’s mane mushroom powders with ground coffee and supports better focus in the mornings and afternoons.

Next, the Chill includes reishi mushroom powder along with cacao mix. It aids in calming your mood and relaxing the mind. You can take it anytime.

The last option is the Defend that consists of plant-based protein, blends of several medicinal mushrooms, and other organic items.

This category also offers four different flavors to enhance your daily taste buds. Defend mushroom supplements are a delicious form of improving the immune system, digestive system, and nutrition.

There are other kinds of supplements products available in Four Sigmatic. However, these three categories stand out the most.

The medicinal mushroom supplements in this company offer various elements, depending on the type of product.

However, the typical natural ingredients include lion’s mane, cordyceps, vitamin B12, Rhodiola, coenzyme Q10, guayusa, ashwagandha, tulsi, and other adaptogens.

Once again, dosages will vary based on the category you select. Most of the mushroom supplements come in powder form. Please follow their official site for further information in this regard.

Real Mushrooms


There is no denying it; the Real Mushrooms are backed by years’ worth of experiences and a reputation that swells the farm with pride. It is much older than most brand names we have enlisted here.

This indicates plenty of options to choose from, depending on your condition or aim. The company and the mushroom are owned by a family that focuses on potent medicinal mushroom extracts.

Its main attractions are the Chaga, turkey tail, cordyceps, reishi, tremella mushroom powder, and capsule accessibility. Plus, other choices include Mushroom Hot Chocolate Mix, 5 Defenders, etc.

Real Mushroom supplements are a great way to boost your body and mind. They are most valued in quality, quantity, and price.

The Real Mushrooms products offer plenty of healthy ingredients based on the type of extracts you select. So, we suggest you visit the official site to view the ingredients of each product individually.

Each product might offer different dosage requirements based on the day/night, activity, workout routine. Follow the directions given on the package/bottle labels to avoid complications.



You love coffee, but the jittery sensation you get leaves you in a foul mood in the morning. People who have faced this situation know fully well how it interrupts the morning rituals.

MUD/WTR is one of the best mushroom supplements that pay attention to this detail. Aside from the minimal yet eye catching black container, the brand emphasizes enhanced energy without caffeine.

Each tablespoon of powder contains specific levels of certain ingredients that we will mention in the next section. The main point is that the mushroom capsules consist of only 1/7 of the caffeine.

Moreover, the four main medicinal mushrooms will ensure you achieve the much-needed strength to feel sharp and calm throughout the day.

MUD/WTR mushroom powder has Chaga, reishi, lion’s mane, cordyceps as the primary extracts. There are also cacao masala chai, sea salt, cinnamon, and sea salt to make it a delicious drink.

Simply add one tablespoon of the mushroom powder in 8 ounces of hot water. Make sure to stir it well before drinking in the morning like coffee.

Mushroom Defense


Despite the slightly steep price, Mushroom Defense is yet another successful supplement brand to this date. The reason is simple – it supports cognitive function with promising improvement.

The product has shown superb resilience against oxidative stress. As a result, the formula will help you strengthen the immune system. In short, your body will achieve a protective shield to fight bacterial and viral diseases.

Additionally, there is a moneyback guarantee after 67 days of consumption. It leaves a favorable impression on mushroom supplements.

Each serving you take will have ten medicinal mushrooms to back your health and wellness. Of course, you will gain mental clarity too.

Mushroom Defense packs in cordyceps mushroom powder, reishi mushroom extract, shiitake mushroom, lion’s mane mushroom, maitake mushroom, turkey tail mushroom, Chaga mushroom, white button mushroom, and black fungus.

Each serving consists of two capsules intake per day.

Organixx 7M+


This is a dietary mushroom supplement that concentrates on anti-aging and immune system features. The main appeal of Organixx 7M+ is the further fermentation of the popular medicinal mushrooms.

Therefore, the process maximizes bioaccumulation and other nutritions. This, in turn, supplies your body with rich compounds like mushroom extracts, antioxidants, beta-glucans, etc.

Overall, the fungi present in the supplements can regulate blood pressure, fortify immunity, lessen inflammation, fight against unhealthy cell growth, and more!

Organixx 7M+ includes organic lion’s mane, Chaga, turkey tail, cordyceps, maitake, reishi, shiitake, etc. It also adds a unique ingredient, kelp extract, to aid liver function.

The mushroom supplements advise two capsules each day for a natural boost.

Pure Essence MyPure Lion’s Mane


There are three categories you can choose from in Pure Essence. However, the My Pure Lion’s Mane has left a rather striking impression on every customer who took it.

The capsules are filled with organic extractions of the particular medicinal mushroom. Hence, it promotes healthy brain function, nerve growth, and immunity.

Your mind will not feel that heaviness and fatigue when working. The nutritional properties will help you focus and stay calm when dealing with day-to-day work pressure.

This mushroom supplement also offers excellent value at a reasonable price.

My Pure Lion’s Mane provides 100% organic lion’s mane mushroom extracts (500mg) rich in beta-glucans.

The manufacturer recommends one capsule a day.

The Genius Brand Genius Mushrooms


When you visit The Genius Brand, you will notice plenty of boosting supplements for various functions. However, our eyes caught the Genius Mushrooms supplements that one can take for overall healthy well-being.

It uses three important mushrooms to deliver a better immune system, cognitive function, and natural energy boost every day. To summarize, you will not have to sort towards bundles of various supplements.

A single capsule a day from this medicinal mushroom supplement formula will boost the body and mind.

Clear focus, better brain health, positive moods, improved endurance for workouts, etc., is possible, thanks to these straightforward mushroom capsules.

Each serving of Genius Mushrooms comprises organic cordyceps (500 mg), organic reishi (500 mg), organic lion’s mane (500 mg), etc.

The Genius Brand Genius Mushrooms suggests three capsules a day with 8 ounces of water. Take it 20 minutes before a meal.

Mushroom Revival


Who does not wish for a healthy life that thrums with vitality, longevity, and calming focus? Mushroom Revival made sure to cover these issues in four separate categories.

Each formula comes in tincture form to let you experience the optimal health benefits according to your desire. The official site openly states how obsessed the brand is with the power of mushrooms.

While Calm, Focus, and Energy tinctures include individual mushroom extracts, the Daily 10 contains a collection of various mushroom blends.

So, you can either go for a particular blend or acquire the Daily 10 – the outcome will be similar. Each product will revive your energy alongside promoting a healthy immune system.

Thanks to their versatile formulations, you can have broad navigation regarding enjoyable improvement.

Daily 10 has cordyceps, lion’s mane, maitake, reishi, shiitake, turkey tail, Poria cocos sclerotia, tremella, Chaga, meshima, carob pod, elderberry, and sour cherry fruit.

  • Focus has lion’s mane, cinnamon bark, etc.
  • Energy comprises cordyceps, guarana seed, ginger rhizome, lemon peel oil, etc.
  • Calm contains reishi, passionflower leaf, Hawthorn leaf and flower, ashwagandha root, vanilla bean, etc.

Mushroom Revival suggests two droppers a day for all four products.

Earth Nutri Performance Energy + Focus


The main feature of Earth Nutri Performance Energy + Focus is the combination of other compounds. According to reliable customer reviews, the supplement is true to its name.

It has a formula that not just utilizes mushroom extracts but also nootropic ingredients. On one side, you achieve a highly improved immune system, energy boost, improved mood, and motivation.

At the same time, the rest of the properties promote brain health, cognitive function, better concentration, alertness, and much more.

This is the kind of supplement that will enhance your performance when exercising, brainstorming, or trying to regain strength. However, we strongly advise asking your doctor first in case of other current medication intakes.

The medicinal mushroom powders offer lychee flavor and little stick-like sachets.

Each Earth Nutri Performance Energy + Focus stick contains 2000 mg of cordyceps, reishi, king trumpet, shiitake, lion’s mane, and turkey tail.

It also includes citicoline, A-GPC, theacrine, L-Tyrosine, acetyl-L, organic caffeine, beetroot concentrate (color), etc.

The mushroom supplement product advises one stick per day mixed in 8 ounces of cold water. Do not forget to shake well and drink it within 30 minutes. Do not take it if you are under 18.

Our Ranking Factors for the 10 Best Mushroom Supplements

You must always ask how one ranks these things. This question will lead you deeper into the unknown knowledge we often ignored before. Not anymore.

We divided the best from the cheap ones through the process below. It will help you decide on the right products for you.


This factor was one of the crucial criteria that determines whether the mushroom supplement you choose is genuine.

So, we first ensured these supplements used real mushrooms. Then there is the issue of the right mushroom among thousands.

We chose mushroom products that only have medicinal mushroom ingredients proven by various tests.

Extraction Techniques

There is never a single method to extract medical mushrooms. However, choosing the appropriate technique for the right mushroom is necessary to acquire maximum extraction.

Take lion’s mane mushroom as an example. This has a soft texture and requires a hot water extraction method. On the other hand, if it is a reishi mushroom, you will need a different technique. We call it alcohol extraction.

As you can see, there is no proper method to follow to achieve a higher concentration of mushroom ingredients. But it is the implementation of the correct method on medicinal mushroom types that will bring about positive feedback.

Production Techniques

Similarly, each company may have different production methods. Nevertheless, it is the correct form of procedure that will result in the best medicinal mushroom product.

The tricky part is these various techniques aid in producing mushroom products that a consumer may choose from according to their needs.

For instance, suppose you require full-spectrum mushroom supplements. Then you will have to opt for companies that specialize in whole fruiting body production.

This method utilizes the entire mushroom to attain optimal benefits for the body.

The second option is when you seek the pure mycelium technique. It is when the companies use mycelium grain production. Here the manufacturers utilize the roots or network of mushroom roots that expand underground.

Now we made sure to add both production methods because the consumer must be given a choice to choose from.


How active are the mushroom ingredients? You see, some medicinal mushroom supplement products offer small dosages of these ingredients. They may be well suited for beginners but will provide tedious progress.

Besides, a few manufacturers hide the low active ingredient properties behind the proprietary label. This is a nuisance as you cannot determine individual classifications of the mushroom ingredients.

We felt strongly against such products and picked those that deliver highly effective dosage per intake.


No matter what supplements you take, they require clinical proof of their positive outcome. Although, most companies do not offer clinical trials that involve expenses from the company budget.

However, many mushroom supplements earned consumer trust because of the provided trials or tests invested by the manufacturer.

Therefore, our selection process ranked high to low, depending on which mushroom supplements are backed by more research and trials.

Manufacturer/Firm Reputation

We gave a pointer to the transparent companies about the medicinal mushroom ingredients, sources, dosages, production methods, extraction methods, etc.

The higher the quality they deliver, the more reliable the firm reputation will be. We simply followed that concept.

Advertisement Transparency

Of course, these trustworthy manufacturers will also be transparent and honest when advertising their mushroom supplements.

However, some mushroom supplement companies overindulge into making people believe the impossible. For example, mushroom supplements have many health benefits, but they cannot cure cancer or tumors.

We avoided adding such mushroom products to our list.


It was a problematic factor since not all manufacturers have a medical specialist that adds higher legitimacy to the proven tests and trials.

Yet, we valued the manufacturers that offer such a degree. It ensures the medicinal mushroom supplements are approved by a certified doctor, along with the tested verifications.

Refund Guarantee

Asking for a refund because the best mushroom supplement did not work does not mean it is faulty. The respected companies are well aware of it.

That is why they have kept the money-back guarantee option open for consumers. So we picked such brands to ensure a refund policy due to unsatisfactory outcomes.

Can You Expect Side Effects with Medicinal Mushrooms?

Taking medicinal mushroom supplements does not have any side effects as long as you follow the recommended dosages. Still, let us give you some examples, just in case.

Mild Side Effects

It is entirely understandable if you are a beginner and feel nervous. One can experience such partial uneasiness the first time and cause nausea.

However, the effect will soon subside once you relax your body and let the mushroom supplements work their way to your immune system.

On the other side, do not expect to feel okay after overdosing on the medicinal mushroom extracts. When you take a higher dosage than advised, you are risking yourself with nausea and discomfort.

Serious Side Effects

If we talk about the severe side effects of medicinal mushrooms, we will have to link magic mushrooms as the trigger.

Some will recognize them as psilocybin mushrooms where the main ingredient is psilocybin. It delivers hallucinogenic effects that can alter the person’s mood, thought, or even perceptions.

Now, all the legal mushroom products are void of this psychoactive component. Therefore, you will not experience hallucinations when consuming them.

Whichever mushroom supplement you select from our list for your health, we assure you of no presence of such properties.

Medicinal Mushroom Supplements: Scientific Evidence

The benefits of medicinal mushrooms are immeasurable. But we need evidence that is backed by science.

Nonetheless, it is a mere tiny fraction of the entire fungi universe that has been discovered. It is like the universe we live in. We are aware of only a small portion, while the billions of galaxies remain uncharted.

Our health is the treasure we hold most dear. Of course, we need proven facts before trying out any mushroom supplement. So here are some.

Cordyceps Mushroom

If you wish to know the best among them all, cordyceps mushrooms hold the optimal position. Many studies have concluded that this mushroom has no bound to improve the mind and body.

The trophy-worthy cordyceps mushrooms grow in Tibet, naturally at the peak altitudes.

Researchers conducted several studies where the mushroom extract improved the immune system, energy, sexual function, and other well-being.

These studies took place in about three months on healthy 50 to 70-year-old patients.

In short, the increase of stamina makes cordyceps mushrooms a popular name among athletics.

Reishi Mushroom

Nothing can beat the reishi mushrooms for their medicinal benefits to the stressed community. This mushroom has been in use ever since traditional Chinese medicine practitioners discovered its perks.

A few studies conducted in recent years exhibited the active ingredients comprising anti-tumor and immune-modulating qualities. Reishi mushrooms are known as the antioxidant powerhouse too.

These studies have also shown the positive impacts selected people had within a short duration.

The reishi mushroom extracts offer enhanced cognitive function, immune system, energy, and calmer mood. Thus, the person can be free of anxiety and sleep soundly at night.

Just a heads up, reishi mushrooms are highly effective at blocking potential terminal illnesses like cancer or tumors. However, do not mistake it for a permanent cure.

Maitake Mushroom

There are plenty of medicinal mushroom supplements that include maitake mushroom as the key ingredient.

According to researchers, it is one of the best medicinal mushrooms that increase the immunity of patients undergoing chemotherapy.

Furthermore, maitake mushroom extracts support digestive irregularities and blood sugar regulation.

The beta-glucans in maitake mushrooms help control blood pressure and cholesterol alongside healthy weight loss.

Shiitake Mushroom

Many of you may recognize shiitake mushrooms as it is also a gourmet cooking ingredient. It is a very popular mushroom, but people are mostly unaware of its medicinal benefits.

Various studies conducted by the researchers proved that shiitake mushrooms are a hidden ingredient behind glowing skin. Of course, it is highly beneficial to regulate cholesterol, liver function, and so on.

The Japanese researchers have even developed a licensed shiitake mushroom extract which is purified to treat gastric cancer patients.

Turkey Tail Mushroom

The turkey tail mushrooms are known for their colorful and tough texture. It is the extract that scientists are keen on.

A few studies have shown incredible support for our immune system, especially when going through cancer treatment. Turkey tail mushroom consists of two essential compounds to improve our immunity.

As a result, there was evidence of resilient cell production in cancer patients due to this exceptional mushroom extract.

Chaga Mushroom

No one would believe that the Chaga mushrooms are the antioxidant powerhouse because of their appearance. Yes, they are downright unpleasant to look at but offer excellent benefits to the body.

The high amount of antioxidants present in this mushroom is of great use to reduce inflammation.

Numerous individual studies showed how Chaga mushrooms could kill certain bacteria and viruses. This allows your body to develop better immunity. Plus, supplements with this mushroom fight against digestive disorders effectively.

Lion’s Mane Mushroom

The name Lion’s mane fits perfectly to the unique and surreal appearance of the mushroom. Lion’s mane is also another top fungi for various mushroom supplements.

This is the kind of mushroom that even contains different properties for your well-being. Lion’s mane mushroom extracts focus on our brain neurons. One of the studies saw a significant stimulation of NGF (Nerve Growth Factor) production.

As a result, a damaged nervous system gets a chance to improve over time while enhancing immunity.

Frequently Asked Questions About Medicinal Mushroom Supplements

Q: Are the medicinal mushrooms I take legal?

A: Yes, or you would not have been allowed to purchase them without approval. The FDA has authorized that mushroom extracts are safe to consume.

These extracts are called GRAS (Generally Recognized As Safe).

Q: What are the controlled substances?

A: Mushrooms that contain hallucinogenic properties fall under the controlled substances. For example, psilocybin is a controlled substance and a psychoactive ingredient. Therefore, it is illegal to sell them in supplements.

Q: Will I get addicted to mushroom supplements?

A: No, but you can experience a need to consume them at a specific time, like a regular schedule.

Q: What is the proper dose for taking medicinal mushroom supplements?

A: Each mushroom supplement product will come with an individual dosage recommended by the manufacturer. You should follow it after consulting with a doctor.

Generally, the doses should contain 1 to 2 g every day. It can vary based on the supplement concentration and mushroom type.

Q: Are medicinal mushrooms the same as other mushrooms?

A: Technically speaking, the other mushrooms you use for cooking do not always possess medicinal properties. But the latter subject has different qualities that support numerous health benefits.

Q: Are there side effects of taking medicinal mushroom supplements?

A: No, but you can feel nausea upon excessive consumption. Besides, further potential reactions may vary according to your medical history. So, consult your doctor first.

Q: Is it safe to consume medicinal mushrooms supplements when breastfeeding?

A: While some mushrooms are okay to eat during pregnancy or breastfeeding, mushroom supplements are still uncertain.

Some species are safe to consume, but others are not confirmed due to the lack of further studies. We recommend you seek an expert’s advice before taking them.

Q: Are the mushroom sources in this list reliable?

A: Although most mushrooms originate from China and India, we chose companies that grow the variety of mushrooms right in the United States.

Some companies are family-owned as well, making the source further trustworthy within the country. Plus, all the ingredients mentioned in all the supplements above are USDA organic certified.

10 Best Mushroom Supplements Conclusion

Choosing the best medicinal mushroom supplements has become a rather difficult task nowadays. A lot of new manufacturers and brands claim to use real mushrooms.

The doubt remains in our minds. Medicinal supplements are not candies that one can purchase from any store without a guarantee.

That is why we stood sturdy against shady companies and brought to you products that real consumers have taken without experiencing any complications.

Medicinal mushrooms come in so many forms – mushroom powder, capsules, gummies, tinctures, etc. What matters is that you achieve the health benefits promised to you with no flashy advertisement.

The 10 best medicinal mushrooms we reviewed are helpful and trustworthy and render quality and value. Good luck to you.

RELATED: Best Immunity Boosters 2021 Top Immune Enhancing Supplements

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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