To lead a healthy life, you need to support all aspects of your body health. Though people may not know it, they load their bodies with toxic substances every day with activities like smoking, high-fat diets, exposure to radiation and industrial chemicals, alcohol consumption, overeating, etc. Most of these activities cause your body to experience oxidative stress, a phenomenon characterized by an imbalance between synthesis and buildup of reactive oxygen species (ROS) in your body tissues that impairs your body’s ability to carry out detoxification of these compounds.
Oxidative stress comes with an increased risk of unfavorable health outcomes, i.e., diabetes, inflammatory conditions, neurodegenerative diseases, e.g., Parkinson’s and Alzheimer’s, cardiovascular problems, e.g., high blood pressure, heart disease, and atherosclerosis (hardening of blood vessels), and certain types of cancer.
Your body requires a healthy balance between free radicals (oxidative species) and antioxidants (compounds that inhibit oxidative damage) to steer clear of these harmful and, at times, potentially fatal health conditions. The best way to do that is to make dietary and other lifestyle measures that help inhibit oxidative stress in your body, e.g., regular exercise, quitting smoking, limiting alcohol intake, etc. However, you can make your detoxification more effective by incorporating resveratrol supplements in it.
What is Resveratrol?
Resveratrol is a plant compound belonging to the stilbenoid class. Plants produce it as a reaction to injury caused by pathogens, e.g., bacteria or fungi. It is found in various foods, e.g., blueberries, raspberries, peanuts, mulberries, red wine, and grapes.
Though most of the research conducted on Resveratrol has been carried out in test tubes and animals, its efficacy in supporting human health is well-supported in the light of scientific evidence. Moreover, the limited research that has been done in humans is primarily focused on the supplemental form of Resveratrol. One serving of a resveratrol supplement can provide you with an antioxidant dose equivalent to drinking 100 glasses of red wine per day.
Resveratrol supplements give your body a potent dose of antioxidants that alleviate all types of oxidative cell damage and boost your body’s natural detoxification process. Resveratrol is one of the most popular antioxidant compounds whose supplements are widely used for inflammation, diabetes, weight loss, arthritis, high cholesterol, and heart disease, among many other health conditions.
The Best Resveratrol Supplements in 2021
Though all resveratrol supplements claim to support inflammation and oxidative stress throughout the body, few are true to their word. As the supplement space is saturated with resveratrol products, you might have difficulty picking out the best supplement to support your health and wellness.
After contacting many health and wellness companies, wading through clinical studies, and conducting some testing of our own, we prepared a list of the safest and most effective resveratrol supplements of 2021. The enumeration of the products in the list carries no bearing on their safety, effectiveness, or overall quality.
- Longevity Activator
- Cymbiotika NMN
- Raw Resveratrol
- Optimized Resveratrol
- MAAC10 Trans-Resveratrol
- Claritox Pro
- Resveratrol Rapid +
- Revitaa Pro
- Reserveage Resveratrol
- Designs for Health Resveratrol Supreme
- Toniiq Resveratrol
- Toniiq Elixr
- Resveratrol 1450
- Vivo Tonic
- The Red Wine Diet
Developed by Zenith Labs, Longevity Activator is infused with a moderate dose of Resveratrol and helps minimize both physical and mental signs of aging. Infused with highly absorbable ingredients, Longevity Activator produces anti-aging effects by boosting the power of hormone telomeres, a region of non-coding DNA at the end of chromosomes that protects your genome from damage.
The supplement carries an additional layer of legitimacy as it is one of the very few products on the list formulated by doctors. The formula contains 25 mg of Resveratrol and some complementary ingredients, i.e., Panax ginseng root, ashwagandha root, astragalus root, green tea leaf extract, taurine, turmeric, berberine, l-carnosine, chebulic myrobalan fruit extract, purslane extract, and desert broomrape, among others. It also contains BioPerine, a proprietary blend that contains ginger root extract, black pepper fruit extract, and phospholipid concentrate from sunflower oil, all of which aid in the absorption of Resveratrol.
The recommended dosage for the supplement is one capsule per day. Priced at $49 per bottle, Longevity Activator comes with a 60-day money-back guarantee.
Developed by Cymbiotika, NMN is a resveratrol supplement that produces anti-aging effects by raising NAD+ levels in your body. The supplement is primarily designed to give you a potent dose of nicotinamide mononucleotide (NMN), a direct precursor of nicotinamide adenine dinucleotide (NAD+). NAD+ is a crucial component responsible for a wide range of body functions, i.e., metabolism, mitochondrial functions, e.g., energy homeostasis, and maintenance of gene expressions.
Cymbiotika’s NMN boosts NMN levels in your body to improve the production of NAD. The increased biosynthesis of NAD helps restore NAD levels in your body as they decline with age. The supplement comes with 400mg of nicotinamide mononucleotide (NMN) and 100mg of Resveratrol that work in synergy with other ingredients to provide you with many health benefits, i.e., improved cognitive health, decreased risk of cardiovascular diseases, enhanced metabolism, enhanced inflammatory response, etc. The complementary ingredients present in the supplement include green coffee extract, rice flour, apigenin, and green tea extract.
The recommended dosage for the supplement is two capsules per day. Priced at $77 per bottle, NMN is backed by a 60-day money-back guarantee and is one of the most high-priced supplements on the list.
Developed by Thorne Research, ResveraCel is a dietary supplement that combines nicotinamide riboside with Resveratrol and a group of cofactors to promote healthy aging. The supplement contains a potent blend of anti-aging ingredients, i.e., quercetin, Resveratrol, and betaine anhydrous. The quercetin present in the supplement improves sirtuin (proteins responsible for regulating cellular health) activity, allowing Resveratrol to stay longer in your body.
Like most supplements on the list, it relies on NAD+ levels to produce anti-aging effects. It supports various mitochondrial functions to modulate cellular aging, metabolic syndrome and reduce the effects of age-related conditions, e.g., cognitive decline.
The reputation of ResveraCel’s manufacturer imparts it an extra layer of legitimacy. Thorne Research is one of the most credible brands in the health and wellness industry. The company partners with 11 United States Olympic teams and collaborates with MayoClinic on health and wellness research. Priced at $48, one bottle of ResveraCel comes with 60 capsules that constitute a month’s supply.
Developed by Garden of Life, Raw Resveratrol is a nutritional supplement promoting healthy aging and preventing age-related conditions caused by oxidative stress. The supplement is formulated to combat free radicals and alleviate oxidative stress throughout your body.
Raw Resveratrol comes with a dual-action formula that acts both as a digestive aid and anti-aging agent. The supplement is infused with probiotics and digestive enzymes that boost your metabolic rate and support your gut health. These digestion-supporting ingredients are added to the formula to eliminate oxidative stress from its primary source, i.e., your gastrointestinal tract.
The supplement contains 350mg of trans-resveratrol sourced from organic cabernet sauvignon grapes and fermented Japanese knotweed root. Additionally, it includes dozens of antioxidant-heavy fruit and vegetable extracts, 500 million CFUs of probiotics, and 16mg of digestive enzymes. One bottle of Raw Resveratrol costs $35.
Developed by Biotivia, Transmax is a resveratrol supplement that comes with a 500mg dose of trans-resveratrol with 98% concentration per serving. The supplement contains polydatin that adds to the bioavailability of Resveratrol and aids in its efficient absorption in the bloodstream. In addition to polydatin, it also contains black pepper extract. The piperine present in black pepper extract significantly increases the amount of Resveratrol absorbed by your body. Due to these absorption-boosting ingredients, Transmax is deemed as one of the most fast-acting resveratrol supplements on the list.
By taking Transmax regularly, you can protect your body from oxidative damage. The supplement purportedly promotes mitochondrial functions, e.g., energy homeostasis, supports cellular health, helps maintain healthy glucose levels, neutralizes free radicals to alleviate oxidative stress, and promotes weight loss by imitating the benefits of calorie restriction diets.
The recommended dosage for Transmax is two capsules a day: one in the morning and one in the evening with 30 minutes before the meals. Priced at $74 per bottle, Transmax is one of the most expensive products on the list.
Developed by Life Extension, Optimized Resveratrol is a nutritional supplement that comes with a 250mg dose of trans-resveratrol per capsule sourced from Japanese knotweed. The supplement also contains complementary ingredients, e.g., quercetin, red grape extract, wild blueberry extract, and fisetin to maximize its anti-aging and antioxidant effects. With 150mg of quercetin and 10mg of fisetin, your body absorbs more Resveratrol than it usually would.
Marketed as a longevity-promoting formula, Optimized Resveratrol defends your body against cellular aging. It promotes gene expression linked to healthy aging, boosts insulin sensitivity, supports mitochondrial functions, boosts your body’s inflammatory response, and mitigates the risk of cardiovascular diseases, e.g., high blood pressure.
The supplement comes from a highly reputable manufacturer and therefore carries an extra layer of legitimacy. Life Extension has been ruling the supplement space for over 40 years and has a track record of producing effective formulas in compliance with Good Manufacturing Practices. Priced at $32 per bottle, Optimized Resveratrol is one of the most inexpensive supplements on the list.
MAAC10 Trans-Resveratrol is a nutritional supplement with 500mg of 99% pure trans-resveratrol and 10mg of BioPerine, a proprietary blend developed by Sabinsa Corporation that acts as a natural bioavailability booster. BioPerine not only enhances your body’s ability to absorb Resveratrol but also certain other ingredients.
MAAC10’s resveratrol supplement is a high potency formula that helps with inflammation, detoxification, energy homeostasis, and metabolism. Like other supplements on the list, MAAC10 Trans-Resveratrol supports mitochondrial functions and supports healthy cellular aging. It relies on sirtuin activation and NAD+ biosynthesis to impact all three longevity pathways, i.e., AMPK, mTOR, and sirtuins.
When it comes to health benefits associated with Resveratrol, this supplement works four times better than other products on the list. Manufactured in a US-based cGMP facility, MAAC10 Trans-Resveratrol is a vegan-friendly supplement containing non-GMO ingredients. It is one of the very supplements on the list that are made in GMP and NSF-certified facilities. Priced at $30 per bottle, MAAC10 Trans-Resveratrol comes with a 60-day money-back guarantee.
Developed by Genics Care, LiGenics is a metabolism-boosting dietary supplement promoting weight loss and supporting cardiovascular health. LiGenics is not primarily a resveratrol supplement. However, it contains 40 mg of Resveratrol per serving. In addition to Resveratrol, the supplement is loaded with many active ingredients, including cayenne pepper, banaba, Asian ginseng, milk thistle, berberine, green tea, Resveratrol, chromium, zinc, and alpha-lipoic acid (ALA).
The metabolism-boosting properties of LiGenics are very much attributable to the Resveratrol it contains. Resveratrol works synergistically with other ingredients to boost the production of fat-burning hormones to activate the body’s natural weight loss mechanisms. LiGenics is marketed as an all-inclusive formula that supports various aspects of your health, i.e., metabolism, vascular function, energy homeostasis, and immune function. Priced at $59, one battle of LiGenics comes with 60 capsules that constitute a month’s supply.
Developed by Jim Benson, Claritox Pro is a dietary supplement that supports the overall health of your body. The supplement contains essential minerals, vitamins, and plant and herbal extracts that provide your body with the antioxidants it needs to fight off free radicals and alleviate oxidative stress. Though it comes with 40 mg of Resveratrol, it is not primarily designed as a resveratrol supplement.
In addition to Resveratrol, Claritox Pro contains Panax ginseng, milk thistle, green tea, berberine, cayenne, banaba, zinc, and chromium. Though there is limited information regarding the working mechanism of the supplement, customer reviews suggest it is a powerful formula that supports your health and wellness, i.e., repairs cell damage, promotes a healthy balance of hormones, supports healthy cellular aging, etc.
Priced at $69, one bottle of Claritox Pro comes with a month’s supply. The recommended dosage for the supplement is two capsules a day.
Resveratrol Rapid +
Developed by Nuzena, Resveratrol Rapid + is a dietary supplement with better nutritional value than most supplements on the list. The supplement is formulated to support healthy blood pressure, boost insulin sensitivity, promote weight loss, alleviate the physical and cognitive symptoms of aging, and promote longevity.
The supplement contains a higher and more potent dose of Resveratrol than most supplements on the list. With a 1,200 mg dose of Resveratrol, Resveratrol Rapid + by Nuzena works ten times better than most supplements on the list. It is a premium quality supplement that does not contain any synthetic compounds or filler ingredients. Resveratrol Rapid + is very competitively priced, with its one bottle priced at $35.
Created by Robert Miller, Revitaa Pro is an all-natural formula that acts as a stress-reliever to promote weight loss and cardiovascular health. It contains the highest-grade Resveratrol sourced from Japanese knotweed.
Though the supplement is primarily marketed as a weight loss aid, it acts as an all-inclusive solution to support various aspects of your health. It provides all health benefits associated with Resveratrol, i.e., improves circulation, delays disease onset in prediabetic patients, optimizes blood sugar levels, boosts your body’s inflammatory response, maintains healthy cholesterol levels, supports cardiac health, prevents hypertension, normalizes hormone levels, enhances skin and hair appearance, and acts as a mood enhancer. Priced at $66 per bottle, Revitaa Pro comes with a 60-day money-back guarantee.
Reserveage’s Resveratrol is a nutritional supplement primarily designed to support healthy aging, heart health, and weight loss. The supplement works with a triactive technology that uses three blends of trans-resveratrol to ensure a steady release of antioxidant defense in your body, lasting up to 4 hours,
It contains Pro-Longevity Factors Blend (a proprietary mix with Japanese knotweed extract), whole red grape, and red wine grape extract (from stems, fruits, seeds, skin, and vines). These ingredients work synergistically to give you a resveratrol dose as powerful as other top-rated ingredients on the list. The supplement also contains quercetin that adds to the bioavailability of Resveratrol to aid its absorption in the bloodstream, making the dose even more potent.
By taking one capsule of Reserveage’s Resveratrol regularly for six months, you can reap anti-aging benefits, e.g., youthful skin, lack of age spots and discoloration, inhibited cognitive decline, etc. Priced at $34, one bottle of Reserveage Resveratrol comes with 30 capsules.
Designs for Health Resveratrol Supreme
Developed by Designs for Health, Resveratrol Supreme is a nutritional supplement packed with only two ingredients, i.e., Resveratrol and quercetin. These ingredients work together to support healthy aging, cognitive health, immune function, and cardiovascular health. The supplement promises to provide a wide range of health benefits by targeting one underlying factor, i.e., oxidative stress.
Though most of the health benefits provided by Resveratrol Supreme are inherent to Resveratrol, quercetin is an essential ingredient as it ensures the efficient delivery of Resveratrol in your bloodstream. The supplement contains 200 mg of trans-resveratrol and 200 mg of quercetin. The Resveratrol present in the supplement is sourced from Asian knotweed, perennial weed abundant in Resveratrol and other plant-based antioxidants.
Resveratrol Supreme also carries an extra layer of legitimacy due to the reputation of its manufacturer. Designs for Health has been offering high-quality products since 1989. The company is widely recognized in the health and wellness industry due to its long-standing commitment to producing premium quality supplements with high-quality ingredients and transparent labeling. One bottle of Resveratrol Supreme costs $61.
Resveratrol supplement by Toniiq comes with one of the highest-grade Resveratrol formulas at a highly competitive price. It offers a 600mg dose of 98% pure trans-resveratrol sourced from Asian knotweed root extract per serving. Though that sounds like a high dose, it’s comparable to other supplements on the list as the dose per capsule remains 300mg. There are no complimentary ingredients and filler compounds.
Priced at $20 per bottle, Toniiq’s Resveratrol is the most low-priced yet effective supplement on our list. One bottle of Toniiq’s Resveratrol comes with 60 capsules that constitute a month’s supply.
Also developed by Toniiq, Elixr is a resveratrol supplement with a few complementary ingredients that add to the anti-aging effects of Resveratrol. In addition to Resveratrol, Elixr contains nicotinamide mononucleotide (NMN) and betaine anhydrous, both of which possess anti-aging properties.
Elixr acts as an all-inclusive anti-aging formula that alleviates both physical and mental signs of aging and promotes longevity. Like most aging supplements on the list, Elixr works by controlling gene expressions.
Elixr provides a potent blend of three of the most effective anti-aging ingredients at $47 per bottle. One bottle comes with 90 capsules.
Developed by Purely Beneficial, Resveratrol 1450 is a dietary supplement that claims to support your cardiovascular health and promote healthy aging with a powerful blend of health-boosting ingredients. The supplement is infused with many antioxidants and plant-based ingredients that help various aspects of your health, e.g., immune, liver, brain, heart, and vascular function.
Resveratol 1450 contains 605 mg of trans-resveratrol complex per serving sourced from Asian knotweed extract. The efficacy of this potent dose is enhanced by complementary ingredients present in the supplement, i.e., grape seed, acai fruit, red wine, and green tea leaf. The supplement contains 725 mg of a polyphenol complex derived from the plants mentioned above.
Priced at $26 per bottle, Resveratrol 1450 is one of the most inexpensive yet effective supplements on the list. It comes from a highly reputable manufacturer, is backed by more than 7,000 reviews on Amazon, with a star rating of 4.6 out of 5.
Developed by Juvenon, BloodFlow-7 is a resveratrol supplement that specifically targets your cardiovascular health. The supplement is infused with seven complementary ingredients that help promote healthy vascular and heart function, e.g., beetroot and green tea leaf.
BloodFlow-7 provides your body with ingredients required to maintain healthy blood circulation, i.e., l-citrulline and trans-resveratrol. These two primary ingredients promote nutritional blood composition, blood circulation, and blood function to keep cardiovascular problems like hypertension at bay. By taking the supplement regularly, you can improve your cardiovascular health, i.e., blood fats, blood sugar levels, blood pressure, plaque formation in the arteries, etc. It mitigates the risk of cardiovascular diseases, e.g., arteriosclerosis, due to its vasodilatory effects.
BloodFlow-7 works by boosting nitric oxide (NO) production in your body. It dilates your arteries by 62%, causing a healthy blood flow. Though the supplement is not meant to treat hypertension, it can lower blood pressure in people suffering from mild to moderate hypertension. However, the product should only be administered according to the doctor’s instructions.
BloodFlow-7 also provides additional benefits, i.e., healthy aging, boosted stamina, improved memory, focus, relief from various types of pain and inflammation, etc. It gives you a 30mg dose of trans-resveratrol per serving. One bottle of BloodFlow-7 costs $30.
Vivo Tonic is a resveratrol-containing dietary supplement that helps maintain healthy blood sugar levels. The formula uses Resveratrol and other active ingredients, i.e., vitamins, minerals, and plant extracts, to regulate your blood sugar levels.
Vivo Tonic contains potent doses of carbolic acid, silymarin, Panax ginseng, berberine, and banana, among other natural blood sugar regulators. Most of the ingredients present in the supplement have been used in traditional medicine for centuries. These ingredients are known to exhibit anti-diabetic properties.
By taking two capsules of Vivo Tonic every day, you can nourish your body with the magical health-giving formula used by monks in Kathmandu to maintain their body balance. With its roots in ancient Buddhist medicine, the formula present is Vivo Tonic is designed to promote healthy blood sugar levels and alleviate its symptoms, i.e., frequent urination, nausea, vomiting, altered breath odor, fatigue, increased thirst, stomachaches, etc.
Though the product comes with limited information regarding its ingredients, its efficacy is backed by thousands of customer reviews. Priced at $79 per bottle, Vivo Tonic is one of the most pricey products on the list.
The Red Wine Diet
The Red Wine Diet is not a nutritional supplement but a guide designed to help you boost your body’s inflammatory response through a diet rich in red wine. The guide walks you through different ways red wine can be used to alleviate inflammation, lose weight, and detoxify your body.
The guide incorporated all the benefits that come with Resveratrol and other compounds present in red wine. Though most diets forbid you from drinking altogether, The Red Wine Diet emphasizes adding red wine to your diet or maintaining your current intake to reap fantastic health benefits.
In The Red Wine Diet, there exists a massive collection of ebooks that apprise you of everything you need to know about the red wine diet and how it works. You also get a list of foods that can sabotage your weight-loss regimens. The Red Wine Diet comes with additional step-by-step weight loss guides, weight loss accelerators, and meal plans. You can get instant access to the digital version of The Red Wine Diet for $15.
How We Ranked The Best Resveratrol Supplements
Every resveratrol supplement in the market claims to target oxidative damage and support your overall body health. However, not all supplements are the same when delivering results, i.e., they do not offer the same quality and are not equally effective.
From the reputation of the product manufacturer to the nutritional value associated with the supplement, everything counts when distinguishing the best products from the worst. Our editorial team used the following criteria to rank the best resveratrol supplements available in the market in 2021:
The dosage of Resveratrol present in the supplement matters the most regarding the product’s effectiveness. Resveratrol dosage was the first thing our editorial team considered when compiling the list. The higher the resveratrol dosage, the more antioxidants your body gets to protect itself from free radicals and other harmful substances. Most of the supplements on our list contain 200 to 500 milligrams of Resveratrol per capsule. However, some supplements come with a mild yet effective dose of 10mg to 40mg.
A resveratrol supplement does not only contain Resveratrol. It comes with many additional ingredients that work synergistically with Resveratrol in supporting your immune function and overall body health. While some complementary ingredients in resveratrol supplements are added for additional benefits, some are added to increase the rate of resveratrol absorption in your bloodstream. Some resveratrol supplements come with other antioxidants belonging to the polyphenols class. While preparing the list, our editorial team considered the nutritional value of complementary ingredients present in the supplements.
Ingredient Transparency & Labelling
When it comes to the ingredients of nutritional supplements, transparency is of utmost importance. High-quality products disclose everything from the concentration of both their primary and secondary ingredients to their sources and origins. While preparing the list, our editorial team was wary of products that hide ingredients and dosages under proprietary blends or vague labeling.
Price & Value
Not everybody has the same budget for buying nutritional supplements. Though some people may want to spend up to $100 a month on dietary supplements, some simply can’t afford to do so. Therefore, our list includes a conglomerate of products belonging to different price ranges. We have featured products for all budgets while emphasizing quality at every price to make sure you get the most bang for your buck.
Honesty in Advertising
As the supplement market is saturated with resveratrol products, you may come across some companies that advertise resveratrol supplements as a treatment for certain diseases. Though resveratrol aids in the treatment of many diseases, its supplementation is not meant to diagnose, treat, or cure any disease. According to the U.S. Food and Drug Administration, Resveratrol and other dietary supplements are only meant to support your health. Supplements that promise to cure a particular disease should not be trusted. While compiling the list, our editorial team utterly disregarded all products that made bogus claims, e.g., advertising Resveratrol as a cure for cancer or promising overnight weight loss.
The manufacturer’s reputation matters a lot when determining the quality and safety of the product. Factors like compliance to Good Manufacturing Practices, production in an FDA-approved facility, transparency, etc., add to the manufacturer’s credibility. All the supplements on our list come from highly reliable companies with a track record of offering safe and high-quality supplements with transparent labeling. However, we were not biased against new companies who have just introduced their products in the market. We considered all the factors mentioned above while preparing the list and not just the company’s age.
Scientific Evidence For Resveratrol Supplements
A great deal of anecdotal and scientific evidence verifies the effectiveness of resveratrol supplements in supporting various aspects of human health. Most of the scientific research on Resveratrol comes from animal studies. However, the limited research on it in humans is equally fascinating. Most clinical studies on Resveratrol focused on its supplemental form, in concentrations higher than obtained from its food sources.
Resveratrol is best-known as an anti-aging agent that reduces both physical and mental signs of aging. The purported anti-aging benefits of Resveratrol include wrinkle-free skin, delay in age-related cognitive decline, and increased lifespan. However, these benefits are not well-supported for human beings as most of these effects have been observed in animal studies, particularly the increase in lifespan.
According to one clinical study, Resveratrol can activate specific genes that combat age-related diseases, e.g., macular degeneration, hypertension, dementia, etc. Another study analogous to this one found that resveratrol supplementation had similar effects to limiting one’s calorie intake, as both could lengthen lifespan.
According to one of the most-shared reviews published in 2016, Resveratrol increased lifespan up to 60% in the organisms studied. This effect was most noticeable in worms and fish, which have no relation to humans whatsoever. Nevertheless, Resveratrol may exhibit similar results in human beings if administered for a prolonged period, as concluded by the researchers.
The current meta-analysis shows that resveratrol supplementation can considerably reduce fat mass and body mass index (BMI). It also suggests that resveratrol intake could lead to increased lean mass while not producing changes in hormonal levels. There were no apparent metabolic or appetite-controlling hormones changes in all studies, i.e., leptin, ghrelin, and adiponectin.
Resveratrol supplements are most commonly taken for hypertension (high blood pressure) and other cardiovascular problems. There are a lot of studies that show that resveratrol supplementation can help regulate healthy blood pressure levels in people suffering from mild to moderate hypertension. Long-term administration of resveratrol supplements can help with severe forms of hypertension. According to a review published in 2015, researchers concluded that the antioxidant properties of Resveratrol could help alleviate high blood pressure.
The research is mixed for systolic (pressure when the heart beats) and diastolic [Text Wrapping Break](pressure when the heart is at rest or in-between heartbeats) pressures. As reported by researchers that conducted the review mentioned above, high doses of Resveratrol could help reduce systolic blood pressure. Systolic blood pressure tends to rise as you age, and your blood vessels become stiffer. The same review also concluded that Resveratrol boosts nitric oxide production to slacked blood vessels, causing the pressure to decrease.
Though more research is needed to make specific conclusions regarding the role of Resveratrol in supporting cardiovascular health, its efficacy in lowering blood pressure is well-supported in the light of scientific evidence. There are no specific dosage recommendations for using Resveratrol as an antihypertensive due to limited scientific knowledge. However, according to the available scientific evidence, high doses of Resveratrol are required to achieve its antihypertensive effects. The higher the resveratrol dose, the greater the NO production. According to a study published on hypertension in 2008, wine polyphenols, e.g., Resveratrol, could improve vascular health in rats with high blood pressure.
Furthermore, Resveratrol also has favorable effects on cholesterol levels. Several clinical studies suggest that resveratrol supplementation could alter blood fats favorably for your health. According to a study performed on mice in 2014, Resveratrol could help solve cholesterol issues in mice by reducing blood lipid levels. Similarly, another study conducted in 2016 concluded that Resveratrol reduced cholesterol levels in mice even when they consumed a high-fat diet. The study also concluded that Resveratrol could lower total cholesterol levels and increase high-density lipoprotein levels in mice, promoting weight loss.
The cholesterol-lowering effects of Resveratrol experienced in mice have been extrapolated in human beings in various studies. Researchers believe that Resveratrol can lower LDL or bad cholesterol in your bloodstream by neutralizing it and, therefore, help inhibit plaque formation in your artery walls. In one human study, participants administered a high dosage of Resveratrol daily for six months. After six months, the LDL levels of participants dropped by 4.5%, and oxidized LDL dropped 20% compared to participants who were given a placebo.
Due to its ability to relieve oxidative stress, Resveratrol can support your brain health in multiple ways. Resveratrol is widely taken in the form of supplements for its neuroprotective effects. Long-term administration of Resveratrol can help slow down age-related cognitive decline and alleviate its symptoms, e.g., memory loss, impaired ability to process information, confusion, etc. There are multitudinous studies that support the effectiveness of red wine in inhibiting age-induced cognitive impairment.
According to many researchers, this neuroprotective property of red wine is attributed to Resveratrol. In a study conducted in 2014, researchers found out that red wine could slow the progression of degenerative brain disorders, e.g., Alzheimer’s. Researchers concluded that the neuroprotective effects of red wine are accredited to the Resveratrol present in it. Resveratrol neutralizes the impact of beta-amyloids, plaque-forming chemicals present in the blood vessels of your brain. Beta-amyloids cause neurodegeneration by inhibiting blood circulation in the brain, increasing the progression of Alzheimer’s and other degenerative brain conditions. The antioxidant effects of Resveratrol prevent plaque formation by restoring the equilibrium between free radicals and antioxidants in your brain tissue, thereby inhibiting the progression of neurodegenerative diseases, e.g., Alzheimer’s.
Some studies also suggest that Resveratrol possesses anti-diabetic properties. Though most studies that corroborate Resveratrol’s anti-diabetic role were performed on animals, the available scientific evidence suggests that it could help boost insulin sensitivity. According to several clinical studies, Resveratrol seems to inhibit the catalytic activity that converts glucose into sorbitol, a sugar alcohol that aggravates the symptoms of diabetes by causing oxidative stress. In some studies, researchers also found that Resveratrol could help diabetic patients in multiple body areas. Researchers believe that it helps diabetic patients with oxidative stress, inflammation, and metabolism. Resveratrol aids in lipid and glucose metabolism due to its ability to activate AMPK, an essential regulator of energy homeostasis that coordinates metabolic pathways.
A significant amount of scientific studies supports the efficacy of Resveratrol in supporting joint health. Joint pain relief is one of the most scientifically well-supported benefits of Resveratrol. There’s ample scientific evidence that suggests that Resveratrol could help relieve joint inflammation and pain. People suffering from joint disorders, e.g., arthritis, dislocations, bursitis, etc., take resveratrol supplements to support their joint health.
In one clinical study, researchers concluded that Resveratrol could prevent further deterioration of the cartilage in degenerative joint disorders. As cartilage deterioration is one of the primary causes of joint pain, Resveratrol can help alleviate joint pain by inhibiting cartilage breakdown. In one animal-based study, researchers injected Resveratrol into the knee joints of arthritic rabbits and found out that it decreased cartilage deterioration.
Though more research is needed to make conclusive statements about the anti-cancer effects of Resveratrol, a large variety of clinical studies suggest that it could prevent tumor growth by altering the gene expression of cancer cells, thereby inhibiting the progression of cancer. In individual studies, Resveratrol has been found to combat several types of cancer cells, i.e., colon, gastric, breast, prostate, and skin cancers. In the majority of these studies, researchers found that Resveratrol prevented the spread of cancer by inhibiting the ability of cancer cells to replicate.
When it comes to nutritional supplements, everything depends on the bioavailability of the ingredients present in them. According to some studies, the bioavailability of Resveratrol is not good enough when administered orally. In one study conducted in 2011, researchers found that oral administration of Resveratrol may not be very effective, and long-term usage is required to reap its benefits through oral intake. That is why resveratrol supplements come with complementary ingredients that aid in the absorption of Resveratrol by making it more bioavailable.
Altogether, more large-scale human-based research is needed to verify these effects of Resveratrol. However, the scientific evidence that is currently available is sufficient to conclude that Resveratrol comes with a wide range of health-supporting effects.
Side Effects of Resveratrol
Resveratrol is safe and well-tolerated by healthy adults in standard dosages. However, the information regarding the suitable and safe dosage of Resveratrol is limited. There’s also little research on its interactions with other drugs.
Resveratrol may impair your blood’s ability to form clots if administered in high doses for a prolonged time. The impaired coagulation ability of the blood may cause bleeding and bruising. This might also increase the risk of resveratrol interactions with prescribed coagulants.
According to anecdotal evidence, there are no severe side effects associated with resveratrol supplementation. However, you should always consult a doctor before taking the supplement. If not administered according to the recommended dosage, resveratrol supplements may cause minor side effects, e.g., nausea, diarrhea, vomiting, and liver dysfunction.
Frequently Asked Questions About Resveratrol
We get zillions of questions regarding resveratrol supplements daily. Here are some most frequently asked questions about Resveratrol:
Q: What is resveratrol?
A: Resveratrol is a plant-based compound that inhibits oxidation, i.e., a chemical reaction that produces cell-damaging compounds called free radicals.
Q: What are the natural sources of Resveratrol?
A: Resveratrol is naturally found in red grapes, berries, peanuts, grape skins, etc., in high concentration.
Q: How do resveratrol supplements support my health?
A: Resveratrol supplements provide your body with antioxidants that fight off free radicals (a type of toxic substance) and prevent oxidative cell damage, thereby supporting various aspects of your health.
Q: What health benefits do resveratrol supplements provide?
A: Resveratrol supplements are used for their anti-aging and anti-cancer properties. Their antioxidant role may help support blood pressure, blood sugar, inflammation, and diabetes symptoms.
Q: How does Resveratrol prevent oxidative damage?
A: Resveratrol belongs to a class of polyphenols called the stilbenoids group. Stilbenoid compounds carry two phenol rings that are bound by an ethylene bridge. They are produced naturally by plants as a phytoalexin, a type of protective antibiotic. Plants release these protective compounds in response to stressful environmental stimuli, i.e., UV radiations, fungal attacks, exposure to harmful bacteria, etc.
Q: Is red wine healthy?
A: Yes, red wine may support your health due to its antioxidant properties. Red wine is infused with zillions of antioxidants, including Resveratrol.
Q: Can resveratrol supplements help with cancer?
A: Yes, resveratrol supplements may help with cancer. Though the evidence supporting the anti-cancer properties of Resveratrol is minimal, some small-scale animal-based studies suggest that it may help prevent cancer progression by killing cancerous cells.
Q: Does resveratrol help with hypertension?
A: Yes, Resveratrol may help prevent mild to moderate forms of hypertension due to its role in boosting nitric oxide production within your body.
Q: Does Resveratrol help with blood fats?
A: Yes, Resveratrol may help maintain a healthy level of fats in the blood. It neutralizes low-density lipoproteins or bad cholesterol and boosts the production of high-density lipoproteins or good cholesterol.
Q: Does Resveratrol help with dementia and neurodegenerative disorders?
A: Yes, Resveratrol may help with neurodegenerative disorders, e.g., Alzheimer’s, and symptoms of age-induced cognitive impairment, e.g., dementia. Resveratrol works by targeting plaques in your brain arteries to enable healthy blood circulation in the brain, thereby slowing the progression of neurodegenerative disease.
Q: How can I take resveratrol?
A: Resveratrol can be consumed through nutritional supplements and resveratrol-rich foods, e.g., grapes, wine, pomegranates, fruit juices, cranberries, blueberries, etc. You can take Resveratrol through dietary supplements that come in the form of capsules or powders.
Q: What is the difference between Resveratrol and trans-resveratrol?
A: Trans-resveratrol is a more bioactive version of its natural counterpart, i.e., Resveratrol. Resveratrol supplements contain trans-resveratrol instead of ordinary resveratrol. Trans-resveratrol is more efficiently absorbed in your bloodstream.
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