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Best Nootropics of 2022 – Compare the Top Nootropic Supplements That Work

Nootropic use is becoming increasingly popular amongst athletes, entrepreneurs, and college students to improve memory, cognition, and brain health.

Nootropics can work by supporting blood flow to the brain, increasing the production of neurotransmitters, and in several other ways. In general, nootropics use a synergistic blend of plants, herbal extracts, vitamins, and minerals.

If you’re an older adult, a worker in a competitive field, a college student, an athlete, or just someone looking to gain an edge, then nootropics might be right for you.

While hundreds of nootropic supplements are available, it can be difficult for you to pick the right one. After all, it is increasingly more challenging to find a legitimate, safe nootropic.

We’ve researched hundreds of nootropic supplements and compiled a list of the 33 best nootropic supplements to improve your cognition. If you’re looking for nootropic supplements, here are the 33 best for 2021 and beyond.

The Top 33 Nootropic Supplements

There are hundreds of nootropic supplements available for purchase nowadays. Some of them can genuinely work while others will not.
Sane Vitaae Helps in better and clear thinking
Mind Lab Pro Enhances brain health and calms the mind
Nuzena Nuero Focus + Soothes the mind to reduce stress and anxiety
NooBru Promotes better mental performance
Nootrogen Reduces fatigue and increases energy level
Ageless Brain Saves the brain from cognitive decline
Onnit Alpha Brain Reduces the chances of age-related brain illness
Hunter Focus Works as a great cognitive enhancer
Qualia Mind Boost mental performance and clarity
Mind Promotes memory and focus alertness
Brain Boost Increases self-confidence and gives mental clarity
NeuroActiv6 Helps in reducing oxidative stress and anxiety-related issues
Synapse XT Helps in getting rid of toxins
NooCube Brain Productivity Improved memory and problem-solving abilities
Mind &MoodReduces depression and enhances sleep quality
PureHealth Research Ageless Brain Improves overall quality of life and well being
Brain Essense Supports clear thinking and problem-solving abilities
Neuro Fuel Maximizes memory and concentration
Cymbiotika Golden Mind Allows faster rate of memory processing
Elm & Rye Nootropics Eliminates the chances of memory loss and promotes overall health
CogniBioticsImproves mental clarity and gut health
Brain C13 Supports cognitive health and mental performance
Amy Myers MD Neuro Live Optimal brain health and mental clarity
Opti Mind Improves mood and sleeping quality
NeuroDecreases social anxiety and depression
Youthful Brain Prevents neurological disorders
Brain Pill Improves brain function and boost memory
Remind Solution Reduces inflammation for overall health and well being
Oweli Neuro Promotes better mood and reduces stress levels
Memory Hack Prevents short term memory loss problem
Pro Mind Complex Instantly boost memory and helps in achieving better mood
Memo Defend Recovers from memory loss and ensures better blood circulation
Memosurge Protects the brain from cognitive damage

Here are our 33 best scientifically-backed nootropics:

Sane Vitaae

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Vitaae is one of the best nootropic supplements. It is manufactured by Sane Laboratories, one of the most trusted names in the supplement industry.

According to SANE, their formula can increase brain energy utilization up to 13.6% to boost brain function and increase membrane turnover by 26% for better cognitive performance.

Ingredients present in the formula work to improve mental clarity, brain function, memory recall, mood, and much more.
IngredientsFolate, acetyl-L carnitine, omega-3 fatty acids, citicoline, CoQ10, vitamin D
Key Highlights
  • Improve brain function
  • Promotes brain cell growth and healthy brain cells
  • Supports the nervous system naturally
  • Boosts brain energy
  • Price $47
    Other Perks
  • 100% money-back guarantee for 365 days
  • Natural ingredients
  • Easily available online
  • Recommended by doctor
  • Mind Lab Pro

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    Mind Lab Pro is one of the most popular brain supplements that improve long-term brain health. Mind Lab Pro comes from Opti-Nutra, a trusted supplement manufacturer with a compressive medical board.

    Mind lab pro is among the best nootropic supplements due to its 11 unique ingredients that focus on 6 pathways of brain- circulation, energy, chemicals, regrowth, protection, and signals. The supplement uses nootropics to support mental function and cognitive health.
    Ingredients Vitamin B6, Vitamin B9, Vitamin B12, Citicoline, Bacopa monnieri, Organic lion’s mane mushroom, Phosphatidylserine, and N-acetyl L-tyrosine.
    Key Highlights
  • Promotes motivation and better mood
  • Increases focus and mental function
  • Prevent cognitive decline
  • Nourishes brain cells growth
  • Price $69
    Other Perks
  • Free shipping worldwide
  • Discount on purchase of more than one bottle
  • Clinically proven ingredients
  • Manufactured in the United States
  • Nuzena Neuro Focus+

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    Nuzena Neuro Focus+ is an elite brain supplement that supports memory recall, focus, and overall cognitive function. It is specially designed by healthcare professionals to optimize brain health and provide natural support to enhance cognitive performance.

    Each serving of this brain pill contains an extensive blend of vitamins, minerals, and herbal extracts.
    IngredientsBacopa extract, DMAE, Niacin, Glutamic Acid and Magnesium
    Key Highlights
  • Support mental acuity
  • Ensures healthy brain cell development
  • Enhances brain power and mental energy
  • Promotes cognitive function
  • Price $30
    Other Perks
  • Support mental acuity
  • Ensures healthy brain cell development
  • Enhances brain power and mental energy
  • Promotes cognitive function
  • NooBru

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    NooBru is a daily nootropic drink designed to support focus, creativity, and produce brain cells to improve cognitive function, considered one of the best nootropic supplements. NooBru is quickly becoming one of the most popular nootropics supplements, thanks to its tasty flavors, natural ingredients, and extensive media marketing campaigns.

    Each version is designed to support immunity, energy levels, focus, clarity, and improve overall cognitive function.
    Ingredients Alpha GPC, Astragalus Membranaceus Extract, Ginger extract, Panax Ginseng, Caffeine Extract, Piperine, Zinc, Ashwagandha, Rhodiola Rosea, Taurine
    Key Highlights
  • Improve Cognitive function and mental clarity
  • Reduces mental fatigue
  • Enhances physical performance
  • Supports healthy liver function
  • Price$ 47.95
    Other Perks
  • Backed with 5-star ratings and positive reviews
  • Hassle-free returns
  • Free shipping over $50
  • Plastic-free packaging
  • Nootrogen

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    Nootrogen is one of the unique brain supplements, designed to support cognition, boost energy levels, relieve stress, and improve focus.

    Nootrogen makes similar claims we’ve seen with other nootropics on our list, and it contains several ingredients that can back up its claims. It is one mind-boosting supplement that offers various nutritional and mental benefits.
    Ingredients L-tyrosine, Magnesium, Vitamin B3, Amino acid, DMAE, Bacopa extract, Vitamin B12, Vitamin B5, Phosphatidylserine
    Key Highlights
  • One of the best nootropic supplements that prevents nervousness and anxiety
  • Promote brain development and brain chemicals
  • Offers a high level of sharp thinking
  • Naturally improve mental performance
  • Price $29.99
    Other Perks
  • Most affordable brain supplement
  • Legal and manufactured in the United States
  • No adverse effects, it is a safe formula
  • FDA approved ingredients
  • Ageless Brain

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    Ageless Brain is a brain supplement designed to improve memory, clarity, and focus. It also helps to reduce brain fog. It is manufactured by Organixx, a leading supplement manufacturer of high-quality nutritional products.

    The Ageless Brain works in several ways to improve cognition. It can enhance blood flow to the brain, increase brain cell regeneration, various cognitive benefits, and reduce brain inflammation that causes brain fog.
    IngredientsCamu camu, cat’s claw, bacopa monnieri, cinnamon, pau d-arco, cacao, dragon’s blood resin, guayusa
    Key Highlights
  • Best nootropic supplement to boost cognitive function
  • Reduces age-related brain disorder
  • Enhanced mental and physical performance
  • Sharpen one’s memory power
  • Price$55
    Other Perks
  • 15% discount on subscription orders
  • 1-year money-back guarantee
  • Safe for long term use
  • GMO and gluten-free supplement
  • Onnit Alpha Brain

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    Alpha Brain promises to support memory, focus, and overall cognition that is why it comes under the list of popular nootropics supplements.

    The supplement is proven to be best as a cognitive enhancer amongst all the participants in the study. This gives Onnit a considerable advantage over the competition.

    The ingredients present in this supplement are specifically meant to improve your focus, energy levels, memory recall, overall cognitive and brain function.
    IngredientsVitamin B6, L-Tyrosine, L-Theanine, Oat straw extract, Phosphatidylserine, Cat’s claw extract, Alpha-GPC, Bacopa monnieri extract, Huperzia serrata extract, L-Leucine, Pterostilbene
    Key Highlights
  • Improve brain function to enhance focus and concentration
  • Increasing mental processing speed for better memory power
  • Reduces stress and anxiety
  • Improve mental performance and prevent slow cognitive decline
  • Price $34.95
    Other Perks
  • Steep discounts on the purchase of two and more bottles
  • Full money-back guarantee
  • No side effects
  • Free shipping on all orders above $150
  • Hunter Focus

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    Hunter Focus is a slightly new nootropic supplement that claims to help you unlock your mind’s potential to achieve more. It claims it can improve focus, creativity, and concentration, keys to modern-day success at home and work.

    Each bottle of Hunter Focus contains 120 capsules, which equal a 30 day supply. In month supply, one can achieve many cognitive benefits and improve brain function naturally without any adverse effects.
    Ingredients Lion’s mane mushroom, Ashwagandha, Citicoline, Passionflower, Baccopa Monnieri, L-Theanine, Phosphatidylserine, Maritime pine bark extract, and Vitamin B12
    Key Highlights
  • Open brain pathways for enhanced brain functions
  • Increases happiness by reducing stress and anxiety
  • Creates problem-solving potential
  • Improved memory retention
  • Price $75
    Other Perks
  • Fully transparent formula with no hidden ingredients
  • 100% natural nootropic ingredients
  • Made under FDA research centers
  • Many positive testimonials
  • Qualia Mind

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    Qualia Mind is also one of the popular nootropics and smart drugs, specially designed to enhance brain function Although it is relatively new, Qualia Mind already has thousands of positive reviews and satisfied customers.

    This brain pill is specially designed to support the body’s own ability to produce brain chemicals and other brain functions that plays a vital role in overall cognitive health. All of the ingredients present in the composition work to boost cognition and to improve brain function.
    Ingredients Huperzia Serrata Leaf extract, Celastrus Paniculatus seed extract, Theobromine, Bacopa Monnieri leaf extract, Ginkgo biloba leaf extract, Velvet bean, Organic Coffeeberry
    Key Highlights
  • Increases drive and productivity
  • Supports long term healthy brain function
  • Enhances memory power and cognition
  • Produces new brain cells to boost brain power
  • Price$59
    Other perks
  • Safe and effective brain supplement
  • Legal to be used by adults
  • Manufactured under GMP facilities
  • 100% Organic components
  • Mind

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    Performance Lab Mind is the flagship product from Performance Lab, one of the premier nootropic companies on the market. According to the manufacturer, this performance lab mind can boost brain energy up to 13.6%, supports healthy focus, memory, speed, and motivation, and help recovery from intense cognitive exertion.
    Ingredients Cognizin citicoline, Sharp-PS phosphatidylserine, Ajipure L-Tyrosine, and maritime pine park extract.
    Key Highlights
  • Improve verbal fluidity
  • Boost self-confidence and mental energy
  • Reduces mental fatigue
  • Responsible for the healthy nervous system and mental processing speed
  • Price $69
    Other Perks
  • 30 days money-back guarantee
  • High quality branded ingredients
  • Gluten-free and vegan-friendly supplement
  • Less shipping charges
  • Brain Boost

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    Brain Boost is a nootropic supplement manufactured by Vital Plan and created by Dr. Bill Rawls, MD. According to the manufacturer, you can improve your memory, focus, mental clarity, energy, mood, stress, overall cognitive functions, and even your gut microbiome by taking Brain Boost.

    Unlike other nootropics that have dozens of ingredients, there are only five ingredients found in Brain Boost. All of the ingredients are proven to support cognitive function.

    If you’re looking for a simple, proven nootropic that actual medical professionals back, then Brain Boost may be the right choice for you.
    Ingredients Lion’s mane extract, cat’s claw, bacopa extract, Sensoril ashwagandha extract, and Ginkgo Biloba
    Key Highlights
  • Enhances mental energy and reduces mental fatigue
  • Supports Memory retention and problem-solving abilities
  • Aid in increasing mental performance
  • Eliminate stress and anxiety symptoms
  • Price $48
    Other Perks
  • 90 days money-back guarantee
  • Natural formula
  • Made in the United States
  • NeuroActiv6

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    NeuroActiv6 is a premium nootropic powdered formula under the category of brain supplements, designed to enhance and protect the brain. It is manufactured by NaturalCell, a popular nutritional supplement company.

    According to the manufacturer, mixing just one scoop of NeuroActiv6 can restore healthy brain function, increase BDNF levels, support healthy cortisol levels, promote neural communications, and prevent oxidative stress in the brain.

    Overall, NeuroActiv6 is a solid choice of nootropic because it not only boosts brain power – it protects the brain as well.
    Ingredients Ashwagandha, Turmeric, Active B energy Complex, Citocoline, Coffee Fruit extract, fruit and vegetable blend, Organic Mediterranean berries
    Key Highlights
  • Supports brain function and mental performance
  • Provides calming effect
  • Enhances mood and sleeping pattern
  • Reduced brain fogging
  • Price $46
    Other Perks
  • 60 days money-back guarantee
  • Contains powerful and natural ingredients
  • Many satisfied customers
  • Renowned manufacturer for over 10 years
  • SynapseXT

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    SynapseXT is a unique brain pill in that it claims to support both brain health and hearing health. It is explicitly targeted towards older adults who are suffering from impaired hearing and cognition.

    According to the manufacturer, SynapseXT can support your hearing, memory, and focus. It claims to eliminate brain inflammation, which is purportedly the cause of brain aging and hearing issues. It uses a blend of vitamins, minerals, and herbal extracts like hawthorn berry, garlic, and hibiscus. Although not common ingredients, there is some evidence these ingredients can work.
    Ingredients Hibiscus extract, Garlic, Hawthorn berry, amino acid and Vitamins
    Key Highlights
  • Support hearing, memory, and focus
  • Enhance brain cells powers to reduce mental fatigue
  • Provides clear thinking and hearing
  • Support nerve growth factor
  • Price $69
    Other Perks
  • Discount on multiple orders
  • 60 days refund policy
  • 100% organic and trademarked ingredients
  • Free worldwide shipping
  • NooCube Brain Productivity

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    NooCube claims to be a “synergistic blend of nootropics which help support and enhance your focus, mental speed, and memory. It uses a combination of vitamins, amino acids, and other essential building blocks for a healthy, well-functioning brain. It was developed by top neuroscientists and uses clinically studied and proven ingredients.

    NooCube uses some of the most well-known nootropic stacks, which can significantly enhance your memory, focus, concentration, learning ability, and overall cognitive function.

    NooCube is a solid nootropic, and if you decide to buy three, get three free, you can significantly enhance the value of your purchase.
    Ingredients Bacopa monnieri extract, L-tyrosine, cat’s claw concentrate, oat straw concentrate, L-theanine, Alpha GPC, marigold extract, resveratrol and amino acids
    Key Highlights
  • Enhances mental performance
  • Supports overall cognitive functioning
  • Optimize brain energy to improve brain function
  • Soothes the brain to provide a calming effect
  • Price $69.99
    Other Perks
  • Buy three get free three bottles
  • 60 days money-back guarantee
  • 1000s satisfied customers
  • FDA approved ingredients
  • Mind & Mood

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    Mind & Mood is a unique nootropic compound in that instead of targeting cognition, Mind & Mood focuses on the emotional side of things. Instead of increasing blood flow or improving neurotransmitter production, Mind & Mood is meant to relieve stress and anxiety to improve brain health. The adaptogenic ingredients of this nootropic supplement work to calm your mind, relieve your stress & anxiety and improve your mood.

    Although not a traditional nootropic, theanine, GABA, and passionflower have been shown to improve cognition. Therefore, Mind & Mood can be reliably used to improve your overall comprehension in conjunction with severe stress and anxiety relief.
    Ingredients Rhodiola, 5-HTP, GABA, saffron extract, L-theanine, passionflower extract, L-tyrosine, Amino acid, and Vitamin B6
    Key Highlights
  • Improve brain cells production
  • Promotes mental performance
  • Improve cognitive function
  • Fast-acting relief from stress and anxiety
  • Price $66.66
    Other Perks
  • Tried and Tested Formula
  • Free shipping all over the United States
  • Manufactured under GMP facilities
  • FDA approved ingredients
  • PureHealth Research Ageless Brain

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    Ageless Brain from PureHealth Research is the second “ageless brain” on our list. However, don’t confuse it with Ageless Brain from the product sold by Organixx.

    PureHealth Ageless Brain is a supplement formulated by Dr. Holly Lucille. It contains several proven ingredients that are proven to support cognition, support brain health, and eliminate inflammation in the brain. It is targeted towards those struggling with an aging brain, but it can help anybody support their cognition.
    Ingredients GABA, huperzine A, caffeine, L-Theanine, Amino acid, Niacin, Pyridoxine, L-Tyrosineand B vitamins
    Key Highlights
  • Eliminate the chances of brain fog
  • Increases memory retention
  • Best to deal with cognitive decline
  • Optimize brain health naturally
  • Price $44
    Other Perks
  • 365 days money-back guarantee
  • Extra bonus on purchase of more bottles
  • 100% organic formula
  • Made in United States
  • BrainEssence

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    BrainEssence is a brain pill that claims to “combine the world’s most profound nootropic nutrients and botanicals to create an exquisite mental support system. It is manufactured by Pure Essence, a health and wellness company that sells various nutritional supplements.

    To reap the benefits of BrainEssence, all you have to do is take two tablets daily with water. The manufacturer claims their product undergoes heavy metal testing and potency testing to ensure you have the very best brain-boosting ingredients.
    Ingredients Acetyl-L-Carnitine, Bacopa Monnieri, Organic Ashwagandha, Mucuna Pruriens, Schizandra Extract, Alpha Lipoic Acid, Phosphatidylserine, Gotu Kola Extract, Rhodiola, Fisetin Extract, Chinese Club Moss Extract
    Key Highlights
  • Provides memory and mental clarity
  • Enhances energy and focus
  • Supports problem-solving abilities
  • Offers healthy stress response
  • Price $30
    Other Perks
  • 100% money-back guarantee
  • One of the affordable nootropic supplements
  • FDA approved ingredients
  • Manufactured under GMP research centers
  • NeuroFuel

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    NeuroFuel from Natural Stacks is one of the nootropic supplements that relies on a patented blend of natural ingredients to support healthy cognition and neuroprotection. According to Natural Stacks, NeuroFuel works as fuel for your neurotransmitters, supporting greater signaling between brain cells. This can improve cognitive functions like memory, critical thinking, learning ability, and more.

    One of the more unique aspects of NeuroFuel is that they provide complete transparency about their ingredients and formula. It traces all of the ingredients and its sources directly on the blockchain, which makes it the only “open source” nootropic on the market right now.
    Ingredients Artichoke Extract, Forskolin, Acetyl-L-Carnitine, L-Phenylalanine, Vitamin B6 and amino acids
    Key Highlights
  • Supports brain cells for mental health
  • Reduces brain fog and cognitive decline
  • Enhances learning and problem-solving abilities
  • Boosts brain energy
  • Price $29.95
    Other Perks
  • High quality and transparent ingredients
  • Works instantly in the neurotransmitters
  • Get 20% off on every subscription
  • Manufactured in GMP Facility
  • Cymbiotika Golden Mind

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    Cymbiotika Golden Mind is a unique nootropic tincture in liquid form instead of a powder or capsule. It comes in a gourmet vanilla chai flavor, making Golden Mind as tasty as beneficial. It is formulated to strengthen the brain’s structure, protect against cognitive decline, and spark peak mental performance.

    To benefit from Golden Mind, you should take seven pumps of the tincture twice per day. This brain pill supports your memory recall, critical thinking, focus, productivity, and overall brain health.
    IngredientsPhosphatidylserine, green tea extract, bacopa powder extract, l-theanine, Rhodiola Rosea, ginseng, organic sea buckthorn oil, Gotu kola extract, amino acids and lion’s mane powder extract
    Key Highlights
  • Promotes brain function
  • Enhances cognitive abilities
  • Supports memory power and focus alertness
  • Increases brain productivity
  • Price $59
    Other Perks
  • Sugar and gluten-free supplement
  • Vegan-friendly brain pill
  • 30 days money-back guarantee
  • Made under GMP practices
  • Elm & Rye Nootropics

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    Elm & Rye is a premium supplement manufacturer that sells a nootropic product simply called “Nootropics.” Nootropics come in tablet form and are designed to improve memory & focus, support increased attention, and increase productivity and stamina.

    Elm & Rye is incredibly transparent with their products as they offer third-party lab tests directly on their website. They also claim to routinely test their ingredients to ensure only the most potent ingredients are used.
    Ingredients Caffeine, bacopa, GABA, rhodiola rosea, Alpha GPC, phosphatidylserine, Huperzine A, and theanine
    Key Highlights
  • Positive effect on memory retention
  • Increases stamina and energy level
  • Improve memory and alertness
  • Enhances mental performance
  • Price $84.99
    Other Perks
  • Discount on subscription orders
  • Clinically studied ingredients
  • Nootropics stack legal in many countries
  • Full money-back guarantee
  • CogniBiotics

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    CogniBiotics is a potent nootropic supplement that improves brain health, mental clarity, learning, memory, and focus. It is unique because it primarily functions by improving your gut flora, unlike most of the nootropics we reviewed. However, it also improves the balance of neurotransmitters, improves blood flow to the brain, and improves BDNF and NGF.

    There are a large number of ingredients in CogniBiotics, which are broken up into three blends. The probiotic blend comprises 30 Billion CFUs with nine individual strains of bacteria. The prebiotic complex contains two compounds that feed the gut bacteria in your gut. Finally, the Chinese herbal blend comprises 17 different adaptogenic and herbal extracts that promote cognition and overall brain health.
    Ingredients Cristaria plicata shell, Eclipta prostrate, Citrus reticulata, Paeonia Lactiflora, Schisandra Chinensis, Cristaria plicata shell, Prebiotic complex
    Key Highlights
  • Improves health and function of the digestive system
  • Reduces the risk of blood clotting
  • Deal with stress and depression
  • Eliminates mental fatigue
  • Price $69
    Other Perks
  • Various bonuses on bulk orders
  • 365 days refund policy
  • Blend of herbal ingredients
  • Manufactured in the United States
  • Brain C-13

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    Zenith Labs developed Brain C-13, and it is said to provide advanced brain health support. According to the manufacturer, its ingredients can support mental awareness, boost clarity and focus, and improve mood and brain energy levels.

    All of the ingredients of this brain pill are designed to work together to enhance your cognitive abilities in some way.

    Zenith Labs is very transparent about its ingredients and doses, and most of the amounts are well within the normal range used in clinical studies.
    Ingredients Ginkgo Biloba, bacopa monnieri, Rhodiola Rosea, DMAE, and turmeric, phosphatidylserine, huperzine A
    Key Highlights
  • Enhance memory power
  • Improve brain health and memory retention
  • Works as a cognitive enhancers
  • Price $49
    Other Perks
  • 180 days money-back guarantee
  • Clinically proven formula
  • Doctor recommended
  • Made under GMP practices
  • Amy Myers MD NeuroLive

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    NeuroLive is among the best nootropic supplements from Amy Myers, MD. Amy Myers MD is a premium nutritional company that sells various supplements, protein powders, bars, and collagen products. NeruoLive is their physician formulated a nootropic with seven brain-supporting micronutrients.

    Ingredients in this nootropic supplement are proven to support cognition & brain health in some way. By taking this NeuroLive, these ingredients can help your focus, memory, thinking, and learning ability. If you’re looking for a doctor-formulated and approved formula, then Neurolive from Amy Myers MD is a solid choice.
    Ingredients Vitamin B6, Theanine, N-acetyl tyrosine, bacopa monnieri, mucuna pruriens, Ginkgo Biloba, Sharp PS phosphatidylserine
    Key Highlights
  • Helps in increasing focus and memory
  • Supports learning ability
  • Support cognition and brain power
  • Enhances mental clarity
  • Price $49.97
    Other Perks
  • Save 15% on every subscription order
  • 90 days money-back guarantee
  • FDA approved ingredients
  • Made in FDA approved research centers
  • OptiMind

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    OptiMind is a popular nootropic designed to improve mental focus, mental energy, and overall cognition. It contains several proven ingredients, all of which can enhance some form of your cognitive functions. All of the ingredients in the formula are common in the nootropic industry.

    There’s nothing exceptional about OptiMind; it’s just a solid nootropic product. If you’re looking for an affordable option, it may be right for you.
    Ingredients Phosphatidylserine, bacopa monnieri , rhodiola rosea, maritime pine bark extract, taurine, vinpocetine, GABA, and caffeine
    Key Highlights
  • Promote focus alertness
  • Reduces anxiety and stress
  • Optimize memory and cognition
  • Boost brain function
  • Price $30
    Other Perks
  • 30 days money-back guarantee
  • Complete natural formula
  • Discount on bulk orders
  • No prescription is required
  • Neuro

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    Neuro is the only nootropic we’ve reviewed that comes in the form of edible gums and mints. According to the manufacturer, by taking Neuro, you can focus your mind, energize your brain, and calm your nerves.

    Neuro sells three individual gums and mints – Energy & Focus, Calm & Clarity, and Ideal State. No matter your goals for cognitive enhancement, Neuro has a product that can support your goals.

    Neuro is not only one of the more unique nootropics on our list, but it’s one of the most affordable too.
    Ingredients Sorbitol, Gum Base, L-theanine, Natural Flavors, Natural Caffeine, Calcium Stearate, Spirulina Flakes, Sucralose, Monk Fruit, Stevia, Pyridoxine
    Key Highlights
  • Soothes nerve cells and give a calming effect
  • Increases clarity and memory retention
  • Promotes cognitive enhancement
  • Supports brain energy and focus
  • Price $21
    Other Perks
  • Discounts offered on larger packages
  • 30 days money-back guarantee
  • Complete natural product
  • Backed with many positive reviews
  • Youthful Brain

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    Youthful Brain is a nootropic supplement made by Vitality Now. It claims to fight memory loss, boost focus & concentration, and eliminate those “embarrassing” senior moments. It comes in tablet form and is taken twice per day.

    According to the website, Youthful Brain was created by a brain health specialist and former NASA scientist, Dr. Sam Walters. He is reportedly a world-renowned memory expert who developed Youthful Brain to help seniors restore their memory recall.
    Ingredients Bacopa monnieri, phosphatidylserine, rhodiola rosea, Ginkgo Biloba, and huperzine A
    Key Highlights
  • Anti Aging formula
  • Boost mental focus and clarity
  • Various mental benefits
  • Promote healthy brain tissues and cells
  • Price $64.95
    Other Perks
  • Multiple bottles at a lower price
  • 60 days money-back guarantee
  • Complete herbal formula with no side effects
  • Recommended by a licensed healthcare provider
  • BrainPill

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    BrainPill is a popular nootropic supplement manufactured by Leading Edge Health, a well-respected supplement company based in Canada. According to the manufacturer, BrainPill is designed to give you an “unfair advantage” over the competition. It claims to eliminate brain fog, fight mental fatigue, boost memory, sustain cognitive energy, and improve learning abilities.

    BrainPill contains proven nootropic ingredients such as citicoline, tyrosine, theanine, vitamin b12, and other proven nootropic ingredients. The formula was also recommended by Dr. Dave David and many other medical professionals, which is a bonus.

    There’s a lot to like about BrainPill. It is doctor recommended, uses premium & proven ingredients, and offers a lengthy money-back guarantee.
    Ingredients Citicoline, tyrosine, theanine, vitamin b12, Bioperine, Folic acid and Cognizin
    Key Highlights
  • Helps in avoiding distractions
  • Improves brain nutrition
  • Nourishes brain tissues and cells
  • Improves multitasking and problem-solving abilities
  • Price $70
    Other Perks
  • 100% natural and safe to use
  • Doctor formulated nootropic supplement
  • Reasonably priced
  • Free worldwide shipping
  • Remind Solution

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    Remind Solution is a nutritional supplement that promises to reverse brain aging and restore healthy memory recall & brain health. According to the official website, Remind can help you fit stress & anxiety, calm your mind, and increase your focus and attention.
    Ingredients St. John’s Wort, L-Glutamine, Phosphatidylserine, Bacopa Monnieri, Ginkgo Biloba, N-acetyl L-carnitine (NALC or NAC), vinpocetine, and Huperzine A
    Key Highlights
  • Increased focus and attention
  • Fights against stress and anxiety
  • Get Clearer thinking
  • Gives sharper mind
  • Price $69
    Other Perks
  • Heavy Discounts for larger purchases
  • 60 days money-back guarantee
  • Safe and fresh ingredients
  • Free shipping all over the United States
  • Oweli Neuro

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    Oweli Neuro simply referred to as Neuro, is a unique nootropic product that supposedly reports zen-like focus. According to the official website, Oweli Neuro can deliver six main benefits. It can support concentration, optimize productivity, improve your mood, fight stress, improve memory recall, and boost your cognitive function.

    Oweli Neuro contains eight main ingredients, all of which are proven to support cognitive performance. Oweli claims their products are routinely tested during and after manufacturing to ensure quality ingredients are used.
    Ingredients B vitamins, n-acetyl-l-tyrosine, zinc, DMAE, bacopa monnieri, Huperzine A, phosphatidylserine, and inositol
    Key Highlights
  • Boost cognitive functioning
  • Reduces the chances of brain fogging
  • Boost memory and focus alertness
  • Long term brain health
  • Price Price- $30
    Other Perks
  • Manufactured using GMP practices
  • Safe and fresh ingredients
  • Long term effect on mental health
  • Vegan-Friendly formula
  • Memory Hack

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    Memory Hack is a nutritional supplement designed to enhance cognition and, more specifically, your memory recall. It is made by Nutrition Hacks, a reasonably new but reputable supplement manufacturer.

    Memory Hack doesn’t disclose any of the ingredients in its’ formula, but it does claim its’ product can restore “total restoration of memory in just six months” to people even with the most significant memory problems. Few nootropics claim this, and restoring full memory is a serious claim to make. It seems highly unrealistic to revive memory in just six months, which is a red flag.
    Ingredients L-theanine Vitamin B3, Vitamin B6, and Vitamin B12 Ginkgo Biloba ​Phosphatidylserine
    Key Highlights
  • Reduces memory problems
  • Promotes brain and mental function
  • Boost cognitive function
  • Enhances brain chemicals
  • Price $69
    Other Perks
  • 60 days money-back guarantee
  • Heavy discount on bulk orders
  • 100% natural ingredients
  • The formula is made under FDA approved facilities
  • ProMind Complex

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    ProMind Complex is a newer nootropic formula supposedly developed by a researcher named Carl Henderson. He claims to have used his decades of experience and research to create the “perfect nootropic supplement.” Despite the fact ProMind uses clinically proven ingredients, the dosages are not listed, which is highly problematic in the supplement world.
    Ingredients Bacopa monnieri, vinpocetine, Huperzine A
    Key Highlights
  • Enhances cognitive function
  • Promotes healthy brain functioning
  • Rejuvenates brain cell regeneration
  • Reduces stress and anxiety
  • Price $69
    Other Perks
  • 60 days money-back guarantee
  • Herbal and high-quality ingredients
  • Sugar-free and GMO-free dietary supplement
  • Vegan friendly
  • Memo Defend

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    Memo Defend is a nootropic supplement that is specifically designed to support better memory recall. It was developed by a researcher named Thomas Taylor, who searched to improve his memory recall.
    Ingredients Juniper berry, hibiscus, green tea extract, vitamin C, niacin
    Key Highlights
  • Recovery from memory loss
  • Reduces mental fatigue
  • Promote neurotransmitters
  • Supports better functioning of the brain
  • Price $69
    Other Perks
  • Fast and free shipping
  • 100% natural ingredients
  • No side effects
  • Clinically proven composition
  • Memosurge

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    Memosurge is the final nootropic product on our list. It claims to use a natural formula to improve cognition in three ways. According to the manufacturer, Memosurge can fire up neurotransmitters in your brain, repair damaged brain cells, eliminate anxiety, and boost energy levels. It claims this process can improve your cognition and overall well-being.
    Ingredients Phosphatidylserine St. John’s Wort, N-Acetyl-L-Carnitine, Bacopa Monnieri extract, Vegetable magnesium stearate, Gelatin (bovine), Silicon dioxide, Microcrystalline cellulose.
    Key Highlights
  • Improve overall health and wellbeing
  • Repair damaged brain nerves and cells
  • Reduces stress and anxiety
  • Boost memory power
  • Price $69
    Other Perks
  • 60 days money-back guarantee
  • Natural ingredients
  • How We Ranked the Best Nootropics

    Virtually every nootropic makes the same promises. They all claim they can significantly enhance your cognition and brain health. However, only the best nootropics can deliver upon these promises.

    Our research team considered several factors when researching individual nootropic products to figure out which nootropics were legitimate and which were not. Here are some of the most critical factors we used to determine the best nootropic compounds:

    Science-backed ingredients

    Certain ingredients have been clinically proven to support cognition. There are decades of research on various vitamins, minerals, and herbal extracts that have proven these ingredients work when taken in specific doses. We gave credit to products that used more science-backed ingredients and dosages and ranked them higher on our list.

    Proper dosages

    Many weak nootropics are only ineffective because they contain the right ingredients with the wrong dosages. For example, a nootropic compound might have a dozen clinically studied ingredients at dosages that are too weak to be effective. This is why we gave credit to nootropics that used the right ingredients at the proper dosage.

    Clinical trials

    Some companies have gone the extra mile to invest in actual clinical trials for their products. These trials are expensive and take a long time, but they give us the best idea of whether a product can work. Many of the companies on our list have gone through the clinical trial process and had their products peer-reviewed and published in medical journals. We gave these products a higher ranking if they could demonstrate a clear benefit.

    Clear advertised benefits

    Many companies make outlandish claims about their products because the supplement industry isn’t regulated. Some companies claim that their products can make your brain “decades younger.” Others claim to restore your memory and cognition in just a few weeks. The best nootropic compounds are very honest and transparent about their benefits. They also make clear benefits as to what their product can do for you.

    Clear ingredient list

    Many supplement companies hide their ingredient list by listing them in the form of “proprietary blends.” These products often use proprietary blends to hide weak or ineffective dosages. Others use them to hide the use of stimulants such as caffeine. This is why we preferred companies that had a clear list of ingredients along with their dosages.

    Manufacturer reputation & third-party testing

    Any supplement should be third-party tested to verify the purity, safety, and potency of said product. We looked at manufacturers with a long-standing reputation for creating effective nootropic products that were safe and effective. We also looked for manufacturers that could verify their products with third-party lab tests.

    Doctor formulated products

    Some of the best nootropic products are formulated by real doctors. Others use an in-house medical advisory board to verify the safety of ingredients and formulas. The more professional certifications we could find, the more comfortable we felt ranking a nootropic product higher.

    Customer reviews

    No nootropic is going to work for everybody – that’s just not how supplements work. That’s why we evaluated customer reviews to determine the experience of the average user. If the reviews were generally favorable, we ranked the product higher. On the other hand, we discounted products that have faked or manipulated their reviews, which is common in today’s eCommerce marketplaces.

    Price & overall value

    Not everyone can afford to spend $200 per month on a nootropic supplement. Some people can only afford $20 to $40 per month. We preferred nootropic compounds that were priced relatively affordably but also still offered a tremendous amount of value. Whether you want to spend $20 a month or $150 a month, we listed a few nootropics that fit your price range.

    Money-back guarantee

    Companies should back their products with an explicit money-back guarantee. After all, no supplement has a 100% satisfaction rate. We preferred companies that offered an explicit 30, 60, 90, or even longer money-back guarantee, which indicates they do indeed stand behind their formulas.

    Nootropic FAQs

    Q. What is a nootropic & what do they do?

    A: A nootropic is any supplement, food, beverage, or other consumable product designed to boost cognitive ability. A Romanian psychologist coined the term nootropic in the 1970s who combined three Greek words to create nootropic. Nootropic roughly translates into “mind turner” or “intelligence.”

    Nootropic supplements can support brain health and cognitive function in various ways. Some boost memory and cognition. Others increase energy levels by using stimulant ingredients. Some even can enhance executive functioning, or they can adjust brain plasticity in different ways.

    Q. How do I take nootropics?

    A: Taking nootropics has never been easier. You can order them online, in stores, or through major online marketplaces like Amazon or Wal-Mart. With most nootropics, you simply take one or two capsules per day with water – sort of like you would with basically any other supplement.

    Q. Are nootropics legal?

    A: Yes, nootropics are legal in the United States and most countries around the world. Nootropics must contain ingredients that use doses “generally recognized as safe” or GRAS to sell in the United States. This means the amounts and components are generally safe when used as directed.

    You also do not need a prescription to purchase nootropics either. If you are dealing with a severe issue related to cognitive problems, then a doctor could issue you a prescription-strength drug to manage your condition.

    Q. Are nootropics safe – what are the side effects?

    A: Generally speaking, most nootropics are safe. As long as you use the recommended dosage instructions on your supplement, you are not likely to experience any side effects or severe adverse reactions. However, when you combine nootropics with drugs, are experimenting with the dosages, nootropics could be unsafe.

    You should always speak to your doctor if you are unsure whether or not a nootropic is safe for you or if you have a medical condition.

    Some nootropics do contain stimulants, which may cause side effects. These side effects include jitters, mild digestive issues like stomach pain or diarrhea, or nausea. Most people experience these side effects when taking products not as directed.

    Q. What are the benefits of nootropics? Who can benefit from nootropics?

    A: People commonly take nootropic supplements to improve cognition, memory, and overall brain health. Some nootropics do target specific areas of awareness, such as memory or critical thinking. Others provide general cognitive support.

    Anybody can benefit from nootropics if they’re looking for a competitive edge. However, the most common users of nootropic compounds are athletes, college students, busy parents, older adults, or entrepreneurs.

    Q. Which is the best nootropic supplement?

    A: Any of the nootropic supplements on our list are excellent nootropic supplements and can help support your cognitive abilities in various ways. You can feel very comfortable knowing all of our nootropic supplements have been thoroughly researched and proven safe and effective.

    The Top 33 Nootropic Supplements Final Recap

    Nootropic compounds continue to increase in popularity and will only likely continue to do so. You can buy nootropics at virtually any popular online or physical retail store.

    A good nootropic will optimize your memory, critical thinking, learning ability, focus, and much more. All of the nootropics on our list have been proven to do so and use clinically studied ingredients.

    If you’re looking for a nootropic supplement, then you should feel very safe knowing any of the 33 nootropics on our list will be the right supplement for you.

    RELATED:7 Best Adderall Alternative Supplements for Natural Brain Support

    Affiliate Disclosure:

    The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


    Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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