Nootropic use is becoming increasingly popular amongst athletes, entrepreneurs, and college students to improve memory, cognition, and brain health.
Nootropics can work by supporting blood flow to the brain, increasing the production of neurotransmitters, and in several other ways. In general, nootropics use a synergistic blend of plants, herbal extracts, vitamins, and minerals.
If you’re an older adult, a worker in a competitive field, a college student, an athlete, or just someone looking to gain an edge, then nootropics might be right for you.
While hundreds of nootropics are available, it can be difficult for you to pick the right one. After all, it is increasingly more challenging to find a legitimate, safe nootropic.
Thankfully, we’ve done the work for you. We’ve researched hundreds of nootropics and compiled a list of the 33 best nootropics to improve your cognition. If you’re looking for a nootropic product, here are the 33 best for 2021 and beyond.
The Top 33 Nootropic Supplements
There are hundreds of nootropic supplements available for purchase nowadays. Some of them can genuinely work while others will not.
- Sane Vitaae
- Mind Lab Pro
- Nuzena Neuro Focus+
- Ageless Brain
- Onnit Alpha Brain
- Hunter Focus
- Qualia Mind
- Brain Boost
- NooCube Brain Productivity
- Mind & Mood
- PureHealth Research Ageless Brain
- Cymbiotika Golden Mind
- Elm & Rye Nootropics
- Brain C-13
- Amy Myers MD NeuroLive
- Youthful Brain
- Remind Solution
- Oweli Neuro
- Memory Hack
- ProMind Complex
- Memo Defend
Here are our 33 best scientifically-backed nootropics:
Vitaae is one of the most popular nootropic formulas. It is manufactured by Sane Laboratories, one of the most trusted names in the supplement industry.
Many nootropic compounds use herbal extracts and vitamins – Vitaae uses antioxidants such as CoQ10 to eliminate inflammation in the brain, which can cause brain aging. According to SANE, their formula can increase brain energy utilization up to 13.6% and increase membrane turnover by 26%.
Each capsule of SANE Vitaae includes folate, acetyl-L carnitine, omega-3 fatty acids, citicoline, CoQ10, vitamin D, and much more. These ingredients work to improve mental clarity, memory recall, mood, and much more. Vitaae should be taken three times a day, instead of two times, which provides you with more active ingredients.
It is competitively priced as low as $47 and comes with a 100% money-back guarantee for 365 days.
Mind Lab Pro
Mind Lab Pro is one of the most popular and most well-known nootropic compounds. Mind Lab Pro comes from Opti-Nutra, a trusted supplement manufacturer with a compressive medical board.
Although it is considerably more expensive than many of the other options on our list, Mind Lab Pro is an ideal nootropic for those looking to get started in the nootropic space.
Each serving of Mind Lab Pro contains two capsules packed with 11 research-backed ingredients. Some of these ingredients are patented and advanced nutrients, including NutriGenesis, which enhances bioavailability and absorption. Other components include bacopa monnieri, citicoline, phosphatidylserine, and lion’s mane mushroom.
All of these ingredients use clinically studied ingredients and doses, which is why Mind Lab Pro is one of the best-rated nootropic supplements. It costs $69 for one bottle and comes with a 30-day money-back guarantee.
Nuzena Neuro Focus+
Nuzena Neuro Focus+ is an elite nutritional supplement that supports memory recall, focus, and overall cognitive function. It is manufactured right here in the United States and is priced at $30 per bottle or $60 for three bottles. This makes Neuro Focus+ one of the most affordable products on the market.
Neuro Focus+ is one of the best-rated nootropic supplements on our list, and each serving contains an extensive blend of vitamins, minerals, and herbal extracts. There’s also a proprietary blend of ingredients such as DMAE bitartrate, glutamic acid, green tea extract, bilberry fruit extract, and other active ingredients.
The most significant advantage to Neuro Focus+ is the value you can get. For just $60, you can get a three-month supply of a potent nootropic product. If you’re looking for a great deal, look no further – Nuzena Neuro Focus+ is probably your best option.
NooBru is a daily nootropic drink designed to support focus, creativity, and productivity. Launched in 202, NooBru is quickly becoming one of the most popular nootropics thanks to its’ tasty flavors, proven ingredients, and extensive media marketing campaigns.
NooBru is targeted towards athletes, older adults, college students, and competitive workers. It contains alpha GPC, vitamin b5, theanine, ashwagandha, choline bitartrate, huperzine A, and other ingredients.
You’ve got two options when purchasing NooBru – shield or advantage. All you have to do is mix the powder with a glass of water or favorite beverage of your choice. Each version is designed to support immunity, energy levels, focus, clarity, and overall cognition.
It costs roughly $55 for a 30-day supply, which puts NooBru in the middle of our price range. They offer a no-hassle refund policy to all customers on all orders.
Nootrogen is a unique nootropic compound designed to support cognition, boost energy levels, relieve stress, and improve focus. It is sold by Vita Balance Inc, a famous supplement company that sells a variety of quality nutritional supplements. Take two capsules per day, and you can experience genuine cognitive enhancement.
Nootrogen makes similar claims we’ve seen with other nootropics on our list, and it contains several ingredients that can backup its’ claims. It includes some unique ingredients like tyrosine, DMAE, and glutamic acid. It also has more familiar ingredients like green tea extract, bacopa monnieri, huperzine, and phosphatidylserine.
In total, there are roughly 30 different ingredients found in Nootrogen. The main advantage is that it only costs around $30 per month, making it one of the more affordable nootropics currently available for sale. It comes with a 30-day money-back guarantee as well.
Ageless Brain is a nutritional supplement designed to improve memory, clarity, and focus. It also helps to reduce brain fog. It is manufactured by Organixx, a leading supplement manufacturer of high-quality nutritional products.
The Ageless Brain works in several ways to improve cognition. It can enhance blood flow to the brain, increase neurotransmitter production, and reduce brain inflammation that causes brain fog.
There are eight ingredients in Ageless Brain: camu camu, cat’s claw, bacopa monnieri, cinnamon, pau d-arco, cacao, dragon’s blood resin, guayusa. While some of these ingredients are not commonly found in nootropics, there is still plenty of evidence that these ingredients can support cognition.
Ageless Brain costs roughly $55 per month for a one-month supply. Alternatively, they offer a 15% discount on subscription orders, saving you approximately $8 per month. All orders of Ageless Brain come with a 1-year money-back guarantee.
Onnit Alpha Brain
Alpha Brain is a famous nootropic brought to the public by the popular comedian and podcast host – Joe Rogan. Alpha Brain promises to support memory, focus, and overall cognition.
Onnit Alpha Brain is one of the only nootropic compounds on our list backed by a peer-reviewed clinical study. It was proven to support overall cognitive function amongst all the participants in the study. This gives Onnit a considerable advantage over the competition.
Each bottle of Onnit Alpha Brain comes with bacopa monnieri, cat’s claw, huperzine, oat straw, Alpha GPC, tyrosine, theanine, phosphatidylserine, and much more. The ingredients are specifically meant to improve your focus, energy levels, memory recall, and overall cognitive function.
Alpha Brain costs $34.95 per bottle with steep discounts to purchase it for as little as $24.47 per bottle. All orders come with a full money-back guarantee.
Hunter Focus is a slightly new nootropic supplement that claims to help you unlock your mind’s potential to achieve more. It claims it can improve focus, creativity, and concentration, keys to modern-day success at home and work.
Each bottle of Hunter Focus contains 120 capsules, which equal a 30 day supply. In total, there are nine ingredients in Hunter Focus, including some of the most proven nootropic compounds like theanine, bacopa monnieri, citicoline, ashwagandha, phosphatidylserine, and lion’s mane mushroom. Other ingredients include passionflower extract, maritime pine bark extract, and n-acetyl-l-tyrosine.
Hunter Focus is available directly from the official website for $75 per bottle, which may be pricier than other options. However, it does contain proven ingredients and does not contain stimulants, so it may be a good choice if you’re sensitive to stimulants. They also claim to offer a full money-back guarantee but don’t offer a timeframe on their website.
Qualia Mind is another popular nootropic supplement from Neurohacker Collective. Although it is relatively new, Qualia Mind already has thousands of positive reviews and satisfied customers.
In total, there are 28 different ingredients in Qualia Mind. The manufacturer breaks down its’ components into separate categories such as nootropics, vitamins, antioxidants, adaptogens, amino acids, herbal tonics, and lipids. All of these ingredients work to boost cognition or to improve brain health.
Some ingredients include phosphatidylserine, theanine, acetyl-l-carnitine, PQQ, vitamin B1, vitamin B6, Alpha GPC, caffeine, Ginkgo Biloba, bacopa monnieri, Huperzine A, and mucuna pruriens. All of these ingredients have been clinically studied and proven to support cognition.
Qualia Mind is one of the best nootropics on the market and is reasonably priced at $59. It comes with a full 100-day money-back guarantee as well. In addition, they sell several different customized versions of Qualia Mind, including Qualia Mind Caffeine Free, Qualia Mind Essentials, and Qualia Focus.
Mind is the flagship product from Performance Lab, one of the premier nootropic companies on the market. According to the manufacturer, the mind can boost brain energy up to 13.6%, supports healthy focus, memory, speed, and motivation, and helps recovery from intense cognitive exertion.
There are only four ingredients in Mind, which include Cognizin® citicoline, Sharp-PS® phosphatidylserine, Ajipure® L-Tyrosine, and maritime pine park extract. All four of these ingredients have been clinically studied and proven to support cognition in some form or another. Both Cognizin® and Sharp-PS® are patented ingredients and the most effective forms of citicoline and phosphatidylserine.
The one drawback to Mind is the price. Mind is not the cheapest nootropic at $69 per bottle, but they offer a 30-day money-back guarantee on all orders. Although they are not the most affordable, Mind is one of the most well-reviewed nootropics and, therefore, is worth trying.
Brain Boost is a nootropic supplement manufactured by Vital Plan and created by Dr. Bill Rawls, MD. According to the manufacturer, you can improve your memory, focus, mental clarity, energy, mood, stress, overall cognitive functions, and even your gut microbiome by taking Brain Boost.
Unlike other nootropics that have dozens of ingredients, there are only five ingredients found in Brain Boost. These ingredients include lion’s mane extract, cat’s claw, bacopa extract, Sensoril® ashwagandha extract, and Ginkgo Biloba. All of these ingredients are proven to support cognitive function.
Brain Boost is available for purchase for $48, an affordable option compared to several other options on our list. All orders come with a 100% money-back guarantee within 90 days of purchase. If you’re looking for a simple, proven nootropic that actual medical professionals back, then Brain Boost may be the right choice for you.
NeuroActiv6 is a premium nootropic powdered formula designed to enhance and protect the brain. It is manufactured by NaturalCell, a popular nutritional supplement company.
According to the manufacturer, mixing just one scoop of NeuroActiv6 can restore healthy brain energy, increase BDNF levels, support healthy cortisol levels, promote neural communications, and prevent oxidative stress in the brain. It contains several vitamins and herbal extracts like ashwagandha, grape seed extract, turmeric, B vitamins, coffee fruit extract, and citicoline.
Overall, NeuroActiv6 is a solid choice of nootropic because it not only boosts brain power – it protects the brain as well. Many ingredients in NeuroActiv6 are proven to work, and NeuroActiv6 won’t break the bank at only $46 for a one-month supply. It also comes with a 60-day money-back guarantee, and the manufacturer provides maximum transparency on its’ ingredients label.
SynapseXT is a unique supplement in that it claims to support both brain health and hearing health. It is explicitly targeted towards older adults who are suffering from impaired hearing and cognition.
According to the manufacturer, SynapseXT can support your hearing, memory, and focus. It claims to eliminate brain inflammation, which is purportedly the cause of brain aging and hearing issues. It uses a blend of vitamins, minerals, and herbal extracts like hawthorn berry, garlic, and hibiscus. Although not common ingredients, there is some evidence these ingredients can work.
SynapseXT is not the most affordable product at $69 per bottle, but the manufacturer does offer steep discounts on multiple bottle orders. You can get a six-month supply for as little as $49 per bottle, which is on the lower end of the range on our list. All orders come with a standard 60-day money-back guarantee.
If you’re suffering from hearing issues or cognitive decline, then SynapseXT may be right for you.
NooCube Brain Productivity
NooCube claims to be a “synergistic blend of nootropics which help support and enhance your focus, mental speed, and memory. It uses a combination of vitamins, amino acids, and other essential building blocks for a healthy, well-functioning brain. It was developed by top neuroscientists and uses clinically studied and proven ingredients.
NooCube uses some of the most well-known nootropic compounds such as alpha GPC, huperzine A, cat’s claw, bacopa monnieri, theanine, and a few other ingredients. These ingredients can significantly enhance your memory, focus, concentration, learning ability, and overall cognitive function.
NooCube starts at $69.99 for one month’s supply and offers a buy three, get three free offer for only $179.99. No matter which package you select from their website, your order is covered by a 60-day money-back guarantee.
NooCube is a solid nootropic, and if you decide to buy three, get three free, you can significantly enhance the value of your purchase.
Mind & Mood
Mind & Mood is a unique nootropic compound in that instead of targeting cognition, Mind & Mood focuses on the emotional side of things. Instead of increasing blood flow or improving neurotransmitter production, Mind & Mood is meant to relieve stress and anxiety to improve brain health.
In total, there are eight different vitamins, minerals, or herbal extracts in Mind & Mood. These ingredients include Rhodiola, 5-HTP, GABA, saffron extract, L-theanine, passionflower extract, L-tyrosine, and Vitamin B6. These adaptogenic ingredients work to calm your mind, relieve your stress & anxiety, and improve your mood.
Mind & Mood starts at $59 per bottle, but discounts are available for larger purchases with as little as $33.33 per bottle. Every order comes with a standard 60-day money-back guarantee and free domestic shipping to the United States.
Although not a traditional nootropic, theanine, GABA, and passionflower have been shown to improve cognition. Therefore, Mind & Mood can be reliably used to improve your overall comprehension in conjunction with severe stress and anxiety relief.
PureHealth Research Ageless Brain
Ageless Brain from PureHealth Research is the second “ageless brain” on our list. However, don’t confuse it with Ageless Brain from the product sold by Organixx.
PureHealth Ageless Brain is a supplement formulated by Dr. Holly Lucille. It contains several proven ingredients like GABA, huperzine A, caffeine, and B vitamins, to support cognition, support brain health, and eliminate inflammation in the brain.
It is targeted towards those struggling with an aging brain, but it can help anybody support their cognition. Taking just a few capsules per day can enhance your memory, focus, and overall cognitive wellness. It can also reduce anxiety and brain fog.
The main drawback to PureHealth Research Ageless Brain is that we don’t know the specific dosage of each ingredient. Unfortunately, the manufacturer uses a proprietary blend, which is a slight problem given the product contains caffeine. However, it was formulated by a medical doctor, and therefore we still feel it is a predominately safe product.
PureHealth Ageless Brain can be purchased for $44 per bottle, and it comes with a full 365-day money-back guarantee. You won’t find a more extended guarantee than this, which is a bonus.
BrainEssence is a nootropic that claims to “combine the world’s most profound nootropic nutrients and botanicals to create an exquisite mental support system. It is manufactured by Pure Essence, a health and wellness company that sells various nutritional supplements.
BrainEssence combines some of the most well-studied nootropic ingredients like bacopa monnieri, acetyl-l-carnitine, KSM-66 ashwagandha, mucuna pruriens, phosphatidylserine, and Rhodiola Rosea. Other ingredients include alpha-lipoic acid, schizandra extract, fisetin stem extract, Gotu kola extract, and huperzine A.
To reap the benefits of BrainEssence, all you have to do is take two tablets daily with water. The manufacturer claims their product undergoes heavy metal testing and potency testing to ensure you have the very best brain-boosting ingredients.
BrainEssence costs $30 for 15 servings, which is more affordable per serving than much of the other nootropic supplements we’ve reviewed. The manufacturer offers a 100% money-back guarantee for 90 days on all orders, which is above average for the nootropic industry.
NeuroFuel from Natural Stacks is a nootropic supplement that relies on a patented blend of natural ingredients to support healthy cognition and for neuroprotection.
In each capsule of NeuroFuel is a blend of potent cognitive enhancing ingredients such as artichoke extract, forskolin, acetyl-l-carnitine, L-phenylalanine, vitamin B6 and more. According to Natural Stacks, NeuroFuel works as fuel for your neurotransmitters, supporting greater signaling between brain cells. This can improve cognitive functions like memory, critical thinking, learning ability and more.
One of the more unique aspects to NeuroFuel is that they provide complete transparency about their ingredients and formula. It traces all of the ingredients and its’ sources directly on the blockchain, which makes it the only “open source” nootropic on the market right now.
Overall, NeuroFuel is a solid nootropic compound with quality ingredients, complete transparency, and it only costs you $30 so it can provide you excellent value compared to many of the other nootropics on our list.
Cymbiotika Golden Mind
Cymbiotika Golden Mind is a unique nootropic tincture in liquid form instead of a powder or capsule. It comes in a gourmet vanilla chai flavor, making Golden Mind as tasty as beneficial. It is formulated to strengthen the brain’s structure, protect against cognitive decline, and spark peak mental performance.
Several proven nootropic ingredients include phosphatidylserine, green tea extract, bacopa powder extract, l-theanine, Rhodiola Rosea, and lion’s mane powder extract. Other components include ginseng, organic sea buckthorn oil, Gotu kola extract, and ocean minerals.
To benefit from Golden Mind, you should take seven pumps of the tincture twice per day. This may help support your memory recall, critical thinking, focus, productivity, and overall brain health.
Golden Mind costs $59 for a one-month supply, which is average in the nootropic industry. The manufacturer claims it is organic, vegan, sugar-free, gluten-free, made in the USA, manufactured using GMP practices, and third-party tested. It comes with a free 30-day money-back guarantee as well.
Elm & Rye Nootropics
Elm & Rye is a premium supplement manufacturer that sells a nootropic product simply called “Nootropics.” Nootropics come in tablet form and are designed to improve memory & focus, support increased attention, and increase productivity and stamina.
There are roughly a dozen ingredients in Nootropics, which consist of vitamins and herbal extracts. These ingredients are amongst the most clinically proven cognitive enhancers, such as caffeine, bacopa, GABA, Alpha GPC, phosphatidylserine, Huperzine A, and theanine.
Elm & Rye is incredibly transparent with their products as they offer third-party lab tests directly on their website. They also claim to routinely test their ingredients to ensure only the most potent ingredients are used.
Overall, Elm & Rye is a solid nootropics supplement with plenty of clinically studied ingredients. However, the big downside to Elm & Rye is the price. Nootropics cost $84.99 for a one-month supply, which is on the more expensive side compared to other nootropics we’ve reviewed. They offer a slight discount for subscribing & save orders, but it is still on the pricier side.
CogniBiotics is a potent nootropic blend that improves brain health, mental clarity, learning, memory, and focus. It is unique because it primarily functions by improving your gut flora, unlike most of the nootropics we reviewed. However, it also improves the balance of neurotransmitters, improves blood flow to the brain, and improves BDNF and NGF.
There are a large number of ingredients in CogniBiotics, which are broken up into three blends. The probiotic blend comprises 30 Billion CFUs with nine individual strains of bacteria. The prebiotic complex contains two compounds that feed the gut bacteria in your gut. Finally, the Chinese herbal blend comprises 17 different adaptogenic and herbal extracts that promote cognition and overall brain health.
CogniBiotics is not the cheapest product, it is priced at $69, but it does take a complete approach to cognition. Therefore, it may be a good option – primarily if other probiotics haven’t delivered results.
Zenith Labs developed Brain C-13, and it is said to provide advanced brain health support. According to the manufacturer, its’ ingredients can support mental awareness, boosts clarity and focus, and improves mood and brain energy levels.
There are roughly a dozen brain-boosting ingredients in Brain C-13, including Ginkgo Biloba, bacopa monnieri, Rhodiola Rosea, DMAE, and turmeric, phosphatidylserine, huperzine A, and more. All of these ingredients are designed to work together to enhance your cognitive abilities in some way.
Zenith Labs is very transparent about its ingredients and doses, and most of the amounts are well within the normal range used in clinical studies. It is reasonably priced at $49 for a one-month supply, which is right in the middle of our range of the products we reviewed. It also comes with a 180-day money-back guarantee, which is much longer than most companies we’ve reviewed.
Amy Myers MD NeuroLive
NeuroLive is a doctor-formulated nootropic supplement from Amy Myers, MD. Amy Myers MD is a premium nutritional company that sells various supplements, protein powders, bars, and collagen products. NeruoLive is their physician formulated a nootropic with seven brain-supporting micronutrients.
The seven ingredients in Amy Myers MD NeuroLive include vitamin B6, theanine, N-acetyl tyrosine, bacopa monnieri, mucuna pruriens, Ginkgo Biloba, Sharp PS® phosphatidylserine. All of these ingredients are proven to support cognition & brain health in some way. By taking this NeuroLive, these ingredients can help your focus, memory, thinking, and learning ability.
NeuroLive is available for $49.97 for a one-month supply with an option to save 15% by subscribing to their auto-shipping program. They offer a 9-day money-back guarantee on all orders and third-party tests to ensure maximum potency, quality, and purity of their products.
If you’re looking for a doctor-formulated and approved formula, then Neurolive from Amy Myers MD is a solid choice.
OptiMind is a popular nootropic designed to improve mental focus, mental energy, and overall cognition. It contains several proven ingredients, all of which can enhance some form of your cognitive functions.
The main ingredient in OptiMind is bacopa monnieri with 55% bacosides. These bacosides are the active chemicals in Bacopa monnieri that reportedly give it its’ benefits. It also contains phosphatidylserine, taurine, vinpocetine, GABA, and caffeine. All of these ingredients are common in the nootropic industry.
OptiMind costs roughly $30 for a 30-day supply, which makes it an affordable nootropic compound. It also comes with a 30-day money-back guarantee, which is standard in the industry.
There’s nothing exceptional about OptiMind; it’s just a solid nootropic product. If you’re looking for an affordable option, it may be right for you.
Neuro is the only nootropic we’ve reviewed that comes in the form of edible gums and mints. According to the manufacturer, by taking Neuro, you can focus your mind, energize your brain, and calm your nerves.
Neuro sells three individual gums and mints – Energy & Focus, Calm & Clarity, and Ideal State. No matter your goals for cognitive enhancement, Neuro has a product that can support your goals.
Neuro is not only one of the more unique nootropics on our list, and it’s one of the most affordable too. Neuro starts at only $21 for a small package, with discounts offered on larger packages. You can get extreme value for your money when using the product, no matter which package you select. In addition, they offer a 30-day money-back guarantee on all orders regardless of which package you choose.
Youthful Brain is a nootropic supplement made by Vitality Now. It claims to fight memory loss, boost focus & concentration, and eliminate those “embarrassing” senior moments. It comes in tablet form and is taken twice per day.
According to the website, Youthful Brain was created by a brain health specialist and former NASA scientist, Dr. Sam Walters. He is reportedly a world-renowned memory expert who developed Youthful Brain to help seniors restore their memory recall.
Youthful Brain contains bacopa monnieri, phosphatidylserine, Ginkgo Biloba, and huperzine A, common nootropic ingredients proven to support cognition. However, Youthful Brain doesn’t disclose the exact dosage of these three ingredients, which is problematic.
A one-month supply of Youthful Brain will cost you $64.95, but multiple bottle purchases can lower this price potentially down to $49.95. Every order comes with a standard 60-day money-back guarantee – no questions asked.
BrainPill is a popular nootropic product manufactured by Leading Edge Health, a well-respected supplement company based in Canada. According to the manufacturer, BrainPill is designed to give you an “unfair advantage” over the competition. It claims to eliminate brain fog, fight mental fatigue, boost memory, sustain cognitive energy, and improve learning abilities.
BrainPill contains proven nootropic ingredients such as citicoline, tyrosine, theanine, vitamin b12, and other proven nootropic ingredients. The formula was also recommended by Dr. Dave David and many other medical professionals, which is a bonus.
There’s a lot to like about BrainPill. It is doctor recommended, uses premium & proven ingredients, and offers a lengthy money-back guarantee. However, it is around $70 for a one-month supply, which is pricier than most other nootropics we researched. This is the main reason it isn’t ranked higher. It’s still an effective and powerful nootropic – there are just other nootropics that give you more bang for your buck.
Remind Solution is a nutritional supplement that promises to reverse brain aging and restore healthy memory recall & brain health. According to the official website, Remind can help you fit stress & anxiety, calm your mind, and increase your focus and attention.
Eight ingredients are listed on the ingredients label, including vinpocetine, huperzine A, Ginkgo Biloba, bacopa monnieri, phosphatidylserine, n-acetyl-l-carnitine, glutamine, and St. John’s Wort. However, some of these dosages are too low to be as effective as other nootropics. This is why Remind is lower on the list.
Like some of the other nootropics on our list, Remind costs $69 per bottle and comes with discounts for larger purchases. It also comes with a 60-day money-back guarantee on all orders, regardless of purchase size.
Oweli Neuro simply referred to as Neuro, is a unique nootropic product that supposedly reports zen-like focus. According to the official website, Oweli Neuro can deliver six main benefits. It can support concentration, optimize productivity, improve your mood, fight stress, improve memory recall, and boost your cognitive function.
Oweli Neuro contains eight main ingredients, all of which are proven to support cognitive performance. These ingredients include B vitamins, n-acetyl-l-tyrosine, zinc, DMAE, bacopa monnieri, Huperzine A, phosphatidylserine, and inositol. All of these ingredients are staples in the nootropic world and are proven to enhance cognition.
Oweli claims their products are routinely tested during and after manufacturing to ensure quality ingredients are used. It is also manufactured in an FDA-inspected label using GMP practices.
It costs around $30 for a one-month supply and comes with a 100-day money-back guarantee, which is longer than a large number of other nootropic compounds we’ve researched. It’s also well-reviewed, and most customers seem to experience genuine benefits while taking Oweli Neuro as well.
Memory Hack is a nutritional supplement designed to enhance cognition and, more specifically, your memory recall. It is made by Nutrition Hacks, a reasonably new but reputable supplement manufacturer.
Memory Hack doesn’t disclose any of the ingredients in its’ formula, but it does claims its’ product can restore “total restoration of memory in just six months” to people even with the most significant memory problems. Few nootropics claim this, and restoring full memory is a serious claim to make. It seems highly unrealistic to revive memory in just six months, which is a red flag.
Like many other supplements on our list, Memory Hack is available for $69 per bottle. Discounts are offered for multiple bottle purchases, and they can be purchased for as little as $49 per bottle. Memory Hack comes with a 60-day money-back guarantee as well.
ProMind Complex is a newer nootropic formula supposedly developed by a researcher named Carl Henderson. He claims to have used his decades of experience and research to create the “perfect nootropic supplement.” Despite the fact ProMind uses clinically proven ingredients, the dosages are not listed, which is highly problematic in the supplement world.
We do know that ProMind Complex contains ingredients like bacopa monnieri, vinpocetine, Huperzine A. However, the exact dosages are not known. It also comes with only 30 capsules in a bottle, making it one of the poorest dosages on our list.
It also costs $69, which doesn’t give you much bang for your buck. It does come with a 60-day money-back guarantee, which is about the only bright spot. Overall, ProMind Complex isn’t a lousy nootropic, but there are better options available.
Memo Defend is a nootropic supplement that is specifically designed to support better memory recall. It was developed by a researcher named Thomas Taylor, who searched to improve his memory recall.
Unfortunately, the main reason that Memo Defend is so low on our list is that it does not do a great job of disclosing the dosages in its’ product. It claims to have juniper berry, hibiscus, green tea extract, vitamin C, niacin, and several other ingredients. However, it hides the dosages behind a proprietary blend.
Memo Defend is also not one of the more affordable products on our list, coming in at $69 for a one-month supply. It offers discounts for multiple bottle orders, but there are still more affordable and other products that provide better value. It also comes with a standard 60-day money-back guarantee.
Overall, Memo Defend isn’t a lousy nootropic product, but there are certainly better options available.
Memosurge is the final nootropic product on our list. It claims to use a natural formula to improve cognition in three ways. According to the manufacturer, Memosurge can fire up neurotransmitters in your brain, repair damaged brain cells, eliminate anxiety, and boost energy levels. It claims this process can improve your cognition and overall well being.
There is limited information about the dosage of ingredients in Memosurge. The ingredients list is clear, and some of the ingredients like bacopa monnieri, n-acetyl-l-carnitine, and phosphatidylserine are proven to work. However, the whole ingredients list is not fully available on the website.
Memosurge is also priced at $69 per bottle, with discounts offered for multiple bottle purchases. It also comes with a 60-day money-back guarantee, which is relatively standard in the industry.
Still, because of a lack of disclosure, Memosurge is not one of the higher-ranked nootropics on our list.
How We Ranked the Best Nootropics
Virtually every nootropic makes the same promises. They all claim they can significantly enhance your cognition and brain health. However, only the best nootropics can deliver upon these promises.
Our research team considered several factors when researching individual nootropic products to figure out which nootropics were legitimate and which were not. Here are some of the most critical factors we used to determine the best nootropic compounds:
Certain ingredients have been clinically proven to support cognition. There are decades of research on various vitamins, minerals, and herbal extracts that have proven these ingredients work when taken in specific doses. We gave credit to products that used more science-backed ingredients and dosages and ranked them higher on our list.
Many weak nootropics are only ineffective because they contain the right ingredients with the wrong dosages. For example, a nootropic compound might have a dozen clinically studied ingredients at dosages that are too weak to be effective. This is why we gave credit to nootropics that used the right ingredients at the proper dosage.
Some companies have gone the extra mile to invest in actual clinical trials for their products. These trials are expensive and take a long time, but they give us the best idea of whether a product can work. Many of the companies on our list have gone through the clinical trial process and had their products peer-reviewed and published in medical journals. We gave these products a higher ranking if they could demonstrate a clear benefit.
Clear advertised benefits
Many companies make outlandish claims about their products because the supplement industry isn’t regulated. Some companies claim that their products can make your brain “decades younger.” Others claim to restore your memory and cognition in just a few weeks. The best nootropic compounds are very honest and transparent about their benefits. They also make clear benefits as to what their product can do for you.
Clear ingredient list
Many supplement companies hide their ingredient list by listing them in the form of “proprietary blends.” These products often use proprietary blends to hide weak or ineffective dosages. Others use them to hide the use of stimulants such as caffeine. This is why we preferred companies that had a clear list of ingredients along with their dosages.
Manufacturer reputation & third-party testing
Any supplement should be third-party tested to verify the purity, safety, and potency of said product. We looked at manufacturers with a long-standing reputation for creating effective nootropic products that were safe and effective. We also looked for manufacturers that could verify their products with third-party lab tests.
Doctor formulated products
Some of the best nootropic products are formulated by real doctors. Others use an in-house medical advisory board to verify the safety of ingredients and formulas. The more professional certifications we could find, the more comfortable we felt ranking a nootropic product higher.
No nootropic is going to work for everybody – that’s just not how supplements work. That’s why we evaluated customer reviews to determine the experience of the average user. If the reviews were generally favorable, we ranked the product higher. On the other hand, we discounted products that have faked or manipulated their reviews, which is common in today’s eCommerce marketplaces.
Price & overall value
Not everyone can afford to spend $200 per month on a nootropic supplement. Some people can only afford $20 to $40 per month. We preferred nootropic compounds that were priced relatively affordably but also still offered a tremendous amount of value. Whether you want to spend $20 a month or $150 a month, we listed a few nootropics that fit your price range.
Companies should back their products with an explicit money-back guarantee. After all, no supplement has a 100% satisfaction rate. We preferred companies that offered an explicit 30, 60, 90, or even longer money-back guarantee, which indicates they do indeed stand behind their formulas.
Can Nootropics Work? – What Science Says About Nootropics
Many nootropic supplement companies make some pretty bold statements about their products and what they can do. But can nootropics work? How do they work? Is there any science behind nootropics? What do clinical trials say about nootropics?
A few decades ago, nootropics were nothing more than an emerging field with little interest or research. However, you can find dozens – if not hundreds of peer-reviewed clinical trials involving nootropics. Some of the best nootropic supplement ingredients are backed by multiple peer-reviewed human clinical trials. We’ll show you some of the research shortly.
One of the most well-studied nootropic compounds is bacopa monnieri, an herbal extract used in Chinese medicine for centuries. In 2001, researchers gave participants just 300mg of bacopa monnieri for 12 weeks. According to the study’s authors, bacopa monnieri was proven to improve cognitive processes. They claimed that it was “particularly effective in improving learning and memory.”
Another study published in 2008 used the same 300mg dose in older adult participants. This study found clear benefits related to information processing, memory, and reaction times. Researchers believe the benefits of bacopa are linked to chemicals known as bacosides, which are found in bacopa. This is why bacopa is one of the most commonly used ingredients in nootropics today. An effective dosage of 300mg to 600mg is all you need per day.
Ginkgo Biloba is similar to bacopa in that it has been extensively studied for decades. In 2001, researchers gave ginkgo and vinpocetine to participants for just 14 days. Researchers noted that the adults taking ginkgo had better memory and faster response times than the placebo group.
Ashwagandha is one of the most popular supplements globally, and it’s considered one of the most effective adaptogens. This means ashwagandha can affect how your body responds to stress.
Traditionally, ashwagandha has been used to combat stress & anxiety for cardiovascular sleep, weight management, and sleep support. In a 20016 study, researchers found that ashwagandha has mind-protecting effects. They found that it could target neurotoxins in the brain that interfere with memory and cognition.
Huperzine A is a popular nootropic ingredient that has been around for decades. In an old study in 1999, researchers in China gave huperzine or a placebo to older participants. They found the participants taking huperzine A saw significant improvements in cognition, memory and reduced symptoms of Alzheimer’s disease. Today, Huperzine A remains one of the most popular nootropic compounds, along with Ginkgo Biloba and bacopa monnieri.
Theanine is often included in the world’s most popular nootropic stacks. Most people take caffeine and theanine together to improve cognition. However, studies have found that theanine can nullify caffeine’s adverse effects, giving you the energy-boosting ingredients of caffeine without the jittery feelings of anxiety. However, theanine appears to have plenty of benefits on its’ own.
For example, in one study, researchers found that taking just 50mg of theanine, or roughly the same amount in two cups of tea, could increase alpha brain wave activity and creativity. Another study confirmed that theanine could complement caffeine in that it can improve cognition and negate the adverse side effects of caffeine like anxiety. That study also confirmed it did not negate the active effects of caffeine as well.
Ginseng, sometimes labeled as Panax ginseng or Korean ginseng, is used to support cognition. One study found that taking just 200 to 400mg of ginseng reduced brain fatigue and improved brain performance. It is thought that this is partly because of ginseng’s ability to improve blood flow to the brain.
Finally, tens of millions of individuals already take a nootropic daily – caffeine. Caffeine is the world’s most popular psychoactive nootropic compound. It’s also the world’s most popular nootropic stimulant as well. The energy-boosting effects of caffeine are already widely documented by dozens of studies. However, there’s plenty of new research available.
In a 2021 study, researchers found that regular caffeine consumption changed the brain’s grey matter. Although temporary, caffeine appears to adjust neural pathways. In the study, 20 healthy young individuals saw a significant improvement in grey matter formation and brain electrical activity after taking caffeine, compared to the placebo group.
Onnit Alpha Brain is one of the few nootropic supplements on our list that has been the subject of a significant clinical trial. In the 2016 study published in Human Psychopharmacology, researchers gave Alpha Brain to 63 adult participants between 18 and 35. Participants either received either Alpha Brain or a placebo over six weeks.
Researchers found that Alpha Brain experienced “significantly improved verbal memory” and “executive functioning” compared to the placebo group. It was one of the first and most extensive studies involving a specific brand of nootropic supplements.
Overall, the very best nootropic compounds available today use proven ingredients to support mood, memory, cognition, and more. It is crucial to use scientifically backed ingredients and doses to maximize the chance that you can experience genuine cognitive enhancement.
Side Effects of Nootropics – Are Nootropics Safe?
In general, it is scarce that you’ll experience any unwanted effects or side effects when taking nootropics in standard doses.
However, it is still possible to experience nausea, headaches, mild digestive discomfort, or other mild symptoms when using a nootropic.
To reduce the likelihood that you experience unwanted effects, you must follow the recommended dosage instructions. Unless you have an underlying health condition, chances are you will not experience any side effects while taking a nootropic compound.
You should be aware that some nootropic compounds contain plant-based ingredients, mushroom extracts, or herbal extracts. Therefore, it is possible to experience allergic reactions to these ingredients.
Other nootropic compounds contain caffeine or other stimulant ingredients. Caffeine is known to cause jitters, anxiety, chest tightness, or nausea, so it is essential to take them in standard dosages.
If you do experience any side effects, then you should stop taking nootropic supplements immediately. It is also essential to speak to your doctor before taking a nootropic supplement or any supplement if you are unsure whether or not the product is right for you.
Nootropic supplements may contain a blend of different ingredients. You should always follow the recommended dosage instructions on the label of your nootropic supplement.
If you purchase a nootropic supplement that is encapsulated, then chances are you’ll take between two to four capsules per day. Other nootropic formulas may be in the form of powder, which should be taken with water, or the beverage of your choice.
Most reputable supplement companies will disclose their dosages. You should avoid supplements that hide behind proprietary formulas. If you are sensitive to caffeine, you should be especially careful when using a proprietary blend product because you may not know how much caffeine is present.
In general, try to use a nootropic compound that is more transparent about its ingredients and dosages.
Q. What is a nootropic & what do they do?
A: A nootropic is any supplement, food, beverage, or other consumable product designed to boost cognitive ability. A Romanian psychologist coined the term nootropic in the 1970s who combined three Greek words to create nootropic. Nootropic roughly translates into “mind turner” or “intelligence.”
Nootropics can support brain health and cognitive function in various ways. Some boost memory and cognition. Others increase energy levels by using stimulant ingredients. Some even can enhance executive functioning, or they can adjust brain plasticity in different ways.
Q. How do I take nootropics?
A: Taking nootropics has never been easier. You can order them online, in stores, or through major online marketplaces like Amazon or Wal-Mart. With most nootropics, you simply take one or two capsules per day with water – sort of like you would with basically any other supplement.
Q. Are nootropics legal?
A: Yes, nootropics are legal in the United States and most countries around the world. Nootropics must contain ingredients that use doses “generally recognized as safe” or GRAS to sell in the United States. This means the amounts and components are generally safe when used as directed.
You also do not need a prescription to purchase nootropics either. If you are dealing with a severe issue related to cognitive problems, then a doctor could issue you a prescription-strength drug to manage your condition.
Q. Are nootropics safe – what are the side effects?
A: Generally speaking, most nootropics are safe. As long as you use the recommended dosage instructions on your supplement, you are not likely to experience any side effects or severe adverse reactions. However, when you combine nootropics with drugs, are experimenting with the dosages, nootropics could be unsafe.
You should always speak to your doctor if you are unsure whether or not a nootropic is safe for you or if you have a medical condition.
Some nootropics do contain stimulants, which may cause side effects. These side effects include jitters, mild digestive issues like stomach pain or diarrhea, or nausea. Most people experience these side effects when taking products not as directed.
Q. What are the benefits of nootropics? Who can benefit from nootropics?
A: People commonly take nootropic supplements to improve cognition, memory, and overall brain health. Some nootropics do target specific areas of awareness, such as memory or critical thinking. Others provide general cognitive support.
Anybody can benefit from nootropics if they’re looking for a competitive edge. However, the most common users of nootropic compounds are athletes, college students, busy parents, older adults, or entrepreneurs.
Q. Are nootropics natural? Are they vegan?
A: Most popular nootropic compounds are natural and contain vitamins, minerals, plants, or herbal extracts. However, some nootropic ingredients are indeed lab-made, which makes them synthetic. You should always inspect the label before purchasing any supplement.
Likewise, most nootropic compounds are vegan in that they do not come with animals in any way. However, some manufacturers do package their ingredients in non-vegan capsules such as gelatin capsules. Therefore, you should inspect the label to see if the tablets are vegan.
Q. When should I take nootropics?
A: Most nootropic compounds require you to take the product in the early morning or early afternoon to support your cognitive abilities. If your nootropic supplement contains a stimulant like caffeine, it is essential to avoid taking them at night because it can interfere with your sleep cycle.
Q. Which is the best nootropic supplement?
A: Any of the nootropic supplements on our list are excellent nootropics and can help support your cognitive abilities in various ways. You can feel very comfortable knowing all of our nootropic supplements have been thoroughly researched and proven safe and effective.
The Top 33 Nootropic Supplements Final Recap
Nootropic compounds continue to increase in popularity and will only likely continue to do so. You can buy nootropics at virtually any popular online or physical retail store.
A good nootropic will optimize your memory, critical thinking, learning ability, focus, and much more. All of the nootropics on our list have been proven to do so and use clinically studied ingredients.
If you’re looking for a nootropic supplement, then you should feel very safe knowing any of the 33 nootropics on our list will be the right supplement for you.
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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.