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Best Nerve Pain Supplements – Review Top Neuropathy Relief Products

Have you been diagnosed with neuropathy? This condition can cause extreme discomfort, leaving you debilitated due to pain and inflammation.

Neuropathy is nerve damage or dysfunction that may result in pain, tingling, numbness, or weakness in the affected areas. The discomfort typically starts in extremities like the hands and feet.

This condition, also called peripheral neuropathy, indicates a problem with the nerves that branch off your spinal cord. Diabetes is often the cause of this dysfunction, and over 60% of people with diabetes experience some degree of nerve pain.

However, there can be other causes, like:

  • Physical damage from falls, accidents, or repetitive stress
  • Autoimmune diseases and infections
  • Health conditions like kidney or liver disorders
  • Medications, including chemotherapy
  • Blood vessel disorders
  • Abnormal vitamin levels
  • Alcoholism
  • Genetic disorders
  • Unknown causes

Many nerve health supplements exist today. Some have been proven to help with pain and inflammation, among other neuropathy symptoms.

With so many options available, how can you know which is ideal for you? Our team researched nerve supplements and created this ranking of the best supplements for neuropathy in 2021.

The Best Nerve Health Supplements for Neuropathy

Our editorial team conducted extensive research to rate the effectiveness of each supplement. We tested and analyzed the products and contacted laboratories and manufacturers.

After this detailed investigation, we found the following supplements to be the best for relieving neuropathy pain in 2021:

  • Nuturna Maximum Strength Neuropathy Support Formula
  • Nerve Control 911
  • Nerve Renew
  • Nervala
  • Nervexol
  • Nerve Rejuv
  • Nuturna Clinical Strength Neuropathy 900
  • Circle Labs CBD
  • Nervogen Pro
  • Neuro Calm Pro
  • Bonus Nerve Pain Guide #1: Neuropathy Revolution
  • Bonus Nerve Pain Guide #2: Neuropathy No More

Come along as we review the top neuropathy supplements! You’ll discover the best formulas to support nerve health.

Nuturna Maximum Strength Neuropathy Support Formula


Nuturna’s Maximum Strength Neuropathy Support Formula is one of the best-selling nerve support formulas available today. This powerful supplement is advertised for under $45 on Amazon.

Nuturna Maximum Strength Neuropathy Support Formula targets nerve pain using alpha-lipoic acid (ALA), benfotiamine, turmeric, L-arginine, and multiple herbal extracts. This supplement is ranked at the top of our list because it has one of the most substantial doses while also being among the most affordable.

A four-capsule serving contains 600 mg of ALA, making it much more potent than most formulas in this ranking. If you choose this product, you’ll be taking the same dose of active ingredients used in clinical trials.

It’s easy to find nerve supplements that seem to contain the right ingredients. However, many of them fall short in terms of dosage. Nuturna Maximum Strength Neuropathy Support Formula offers a potent formula including 18 vitamins, minerals, and herbs that target nerve pain in multiple ways.

Nerve Control 911


Nerve Control 911 is a nerve-calming formula from PhytAge Labs, a reputable research and development company for many years. This supplement contains only natural ingredients that target neuropathy pain resulting from diabetes and other conditions.

A daily dose of two capsules can help relieve neuropathy symptoms and bring benefits like:

  • Reduced pain
  • Improved voluntary and involuntary muscle function
  • Reduced inflammation
  • Improved transmission of information between the central nervous system and the rest of the body
  • Reduced anxiety and lower blood pressure
  • Better sleep

Nerve Control 911 contains high-quality ingredients derived from several healing plants, including the California poppy, Corydalis yanhusuo, passionflower, prickly pear, and marshmallow root.

Nerve damage can often lead to infections that get out of control. Sometimes, amputation may be the only option for patients with severe neuropathy. However, this formula resolved one woman’s nerve symptoms and allowed her to keep all four limbs.

This supplement is second on our list because of the fantastic benefits listed on the Nerve Control 911 website. However, you don’t have to take our word for it. Keep reading to compare this product with other neuropathy pills.

Nerve Renew


Nerve Renew is an advanced nerve support formula that harnesses the power of alpha-lipoic acid and B vitamins to treat neuropathy. Taking two capsules daily will flood-damaged nerves with antioxidants. As healing occurs, pain, discomfort, and numbness decrease.

In addition to the full spectrum of B vitamins, Nerve Renew contains vitamin D3 and extracts of the following herbs:

  • Feverfew
  • Passionflower
  • Skullcap root
  • Oat straw

Nerve Renew boasts a unique form of alpha-lipoic acid called R-ALA. It’s soluble in water and fat, making it easier for the body to absorb and use.

This supplement can help promote natural nerve repair and pain relief. It can take away numbness and tingling while giving you a natural energy boost.

  • Nerve Renew Price: $69 for 60 capsules ($49 with a free trial and automatic monthly shipments)



Nervala, a supplement from Barton Nutrition, claims to relieve pain, numbness and tingling by “cooling down” overheated nerves. According to the manufacturer, oxygen-free radicals cause inflammation that attacks and damages cells.

This supplement is not indicated for people whose neuropathy is a result of:

  • Trauma
  • Surgery
  • Infections
  • Carpal tunnel syndrome
  • Autoimmune disorders
  • Toxins, like chemotherapy and heavy metals
  • Tumors

The Nervala formula is a proprietary blend of benfotiamine (75 mg) and alpha-lipoic acid (600 mg). These ingredients target and neutralize the free radicals that cause nerve damage. You need just one capsule daily to start seeing results.



Nervexol targets neuropathy pain through the use of omega-3 fatty acids. It contains CalaMarine, derived from a type of squid rich in these nutrients.

Additional ingredients include:

  • R-alpha lipoic acid
  • Benfotiamine (B1)
  • Methylcobalamin (B12)
  • Ubiquinol (coenzyme Q10)
  • Riboflavin (B3)
  • Vitamin B6
  • Vitamin D3
  • Passionflower
  • California poppy
  • Corydalis

Iaso Nutra Group is confident this product will reduce numbness and tingling and offers a money-back guarantee for 180 days. Shipping is free within the U.S. if you purchase at least a two-month supply.

Nerve Rejuv


Nerve Rejuv is a supplement from Golden After 50 that aims to help older adults with nerve pain. It’s indicated for both diabetic and non-diabetic neuropathy. A daily serving of two capsules of this formula can help ease numbness, tingling, and pain.

The Nerve Rejuv formula includes:

  • Alpha-lipoic acid, an antioxidant
  • Turmeric to fight inflammation
  • Vitamins D, B6, B12, thiamine, and riboflavin, which strengthen the immune system and reduce inflammation
  • Amino acid acetyl-L-carnitine to help the body produce energy
  • Chinese skullcap extract, an anti-inflammatory
  • Feverfew to fight pain
  • Passionflower extract, which soothes the nervous system

According to the manufacturer, these ingredients can help regenerate damaged nerve endings. After 50 also reports this supplement can help with other types of pain, such as those caused by shingles and fibromyalgia.

Nuturna Clinical Strength Neuropathy 900


Clinical Strength Neuropathy 900 is the second supplement from Nuturna on our list. It’s a top seller on Amazon and other online stores. As a result, it may sometimes be out of stock.

Neuropathy 900 is similar to other Nuturna supplements in that it contains potent doses of active ingredients. It boasts 900 mg of alpha-lipoic acid in the six-capsule daily serving. The manufacturer suggests taking three in the morning and three in the evening.

Clinical trials usually use between 300 and 900 mg of ALA. Through this supplement, Nuturna offers a dose at the high end of that spectrum.

In addition to the hefty amount of ALA, Neuropathy 900 contains L-arginine, organic turmeric, acetyl-L-carnitine, and other herbal extracts. A total of 18 ingredients help reduce nerve pain and improve your immune function.

Circle Labs CBD


Circle Labs offers topical cannabidiol (CBD) creams, tinctures, and balms to soothe diabetes-related nerve pain. Many people find these products helpful, and some say CBD is the only natural treatment that works for them.

Products available from Circle Labs include:

  • CBD Pain & Tension Balm
  • Triple Strength CBD Pain Stick
  • CBD/CBDa oils and tinctures

According to the manufacturer, these supplements can help your body recover nerve function when used daily. Some patients report that Circle Labs CBD products provide powerful relief of pain and other neuropathy symptoms.

If you’ve already tried other nerve supplements from this list without success, you may want to try Circle Labs CBD. The products are unique and might be the right solution for you.



NervogenPRO is a neuropathy supplement that contains low doses of five active ingredients. They include:

  • Passionflower
  • Corydalis
  • California poppy seed extract
  • Marshmallow root
  • Prickly pear extract

The manufacturer aims to alleviate the pain, tingling, and numbness associated with neuropathy through this formula.

This supplement comes in near the bottom of our ranking because it lacks potency. NervogenPRO contains only 145 mg of passionflower and less than 110 mg of each of the other ingredients. Thus, the dosage is significantly lower than that of its competitors.

Despite the low strength, the price is the same as for the more potent formulas. While NervogenPRO might work for mild neuropathy issues, it’s unlikely to make a difference in more severe cases.

Neuro Calm Pro


Neuro Calm Pro differs from the other products on this list in that it supports hearing health. Designed to help with tinnitus, this formula can soothe damaged and irritated nerves in other parts of the body, too. In this way, it may alleviate neuropathy symptoms.

Researcher Gerard Watson created this unique supplement with the following ingredients:

  • Yam
  • Dong Quai
  • Motherwort
  • Pacific kelp
  • Hops extract
  • Fenugreek
  • L-tyrosine
  • Black cohosh oat grass
  • Blessed thistle

If you struggle with both tinnitus and neuropathy, this could be the best formula for you. The same company also manufactures the Neuro Deep Calm supplement that offers similar benefits.

Bonus Nerve Pain Guide #1: Neuropathy Revolution


Some neuropathy sufferers find relief by using supplements alone. Others combine pills with other treatments to get better results.

Neuropathy Revolution is a guide containing holistic treatments for nerve damage. It consists of a seven-step system, including changes in diet and lifestyle, that can help reduce or completely stop nerve pain.

Mark Fellers, the author of Neuropathy Revolution, offers a money-back guarantee should the suggested techniques have no impact on your symptoms. In 2021, this book also comes with the Diabetes Protocol eBook, which contains tips on treating the root cause of type 2 diabetes.

Bonus Nerve Pain Guide #2: Neuropathy No More


Jodi Knapp has written an eBook called Neuropathy No More. This publication, released through Blue Heron Health News, teaches natural ways to improve neuropathy symptoms.

According to the author, patients can take control of the factors that can worsen their nerve pain. In this way, some may find their symptoms disappear entirely. Knapp advocates changes in diet and lifestyle to avoid the use of drugs.

A 60-day money-back guarantee lets you receive a refund if the treatment plan doesn’t work for you.

How We Ranked The Best Nerve Health Supplements

You’ll find dozens of supplements online that claim to ease nerve pain. However, not all of them work, and some contain untested ingredients.

Other formulas have reliable components but in doses too low to produce the desired effect. We considered the following factors to develop this ranking of the best neuropathy supplements:

Price & Value

Reputable nerve supplements can cost between $20 and $100 for a month’s supply. Our ranking includes products with a wide range of prices, with a preference for those that provide good value. In this way, patients who seek reliable neuropathy treatments can find something that fits their budget.

Clinically Proven Ingredients

Neuropathy affects millions of people around the globe. Researchers have studied plants, vitamins, herbal extracts, and minerals to determine their impact on this condition. We chose supplements that used the best ingredients possible, as evidenced in clinical studies.

The Honesty of Advertised Benefits

Some nerve pain supplements make outrageous claims that seem too good to be true. For example, they may say they can:

  • Cure neuropathy altogether
  • Eliminate diabetes
  • Solve all your health problems

Other products advertise real benefits, such as supporting nerve health or helping maintain blood sugar within a healthy range.

Supplement manufacturers can’t legally claim their product cures or prevents any disease. We preferred supplements with a higher degree of honesty in their advertising.

Effective Doses

A neuropathy supplement may contain proven ingredients but at the wrong dosage. If it provides too little of the active agents, it may not be effective.

Companies may also refuse to publish dosage information, alleging that the formula is proprietary. We didn’t list supplements unless they provided composition information. We preferred those that indicated doses similar to those used in research studies.

Manufacturer Reputation & Location

We ranked supplements higher if they were manufactured by companies that are well-known and reputable. Lesser-known providers appear lower on the list, especially if they disclosed little information about their ingredient sources and manufacturing location.

Transparent Labels

Transparency in labeling is critical for those who suffer from diabetic neuropathy. You need to know exactly what’s going into your body.

We gave preference to companies that listed all ingredients and their quantities. It would be impossible to compare formulas or determine their effectiveness based on clinical trials without this information.

Proven Benefits

We analyzed customer reviews and tested formulas to determine which supplements work. Then, we selected those that provide clear evidence of their effectiveness. The ones in the above ranking have been shown to relieve numbness, tingling, or pain in the extremities.

We can’t be exactly sure how quickly each supplement may work for you, but all the ones on the list should be effective.

Medical Advisory Board

Reputable supplement companies typically have a medical advisory board made up of several professionals. They include:

  • Traditional doctors
  • Certified dietitians
  • Naturopathic doctors
  • Other health and wellness personnel

We avoided ranking supplements whose manufacturers had no advisory board.

Scientific Evidence for Neuropathy Supplements

Few nerve pain supplements have been through clinical trials. Nevertheless, many individual ingredients in these formulas have a significant amount of research supporting their efficacy. Below, we’ll summarize the results of studies that show which components work toward relieving neuropathy symptoms.


This amino acid is a popular ingredient in neuropathy supplements. The human body produces this substance in the liver and kidneys. It’s known to support cognitive and physical energy.

A few small studies have shown that acetyl-L-carnitine supplements can help relieve nerve pain. One review reported this amino acid improved nerve function in patients with diabetic neuropathy. Another study indicated it didn’t make a significant difference.

B Vitamins

Many neuropathy supplements contain B vitamins, especially B6 and B12. Others include a specific combination of B complex vitamins.

A 2014 study concluded that vitamin B12 deficiency could lead to neuropathy and other health problems. Researchers also found that nerve dysfunction due to lack of vitamin B12 usually began in the feet. If you have nerve pain and low B12 levels, supplements containing this vitamin could improve your symptoms.

In the same research project, scientists studied the effect of vitamin B6 on neuropathy. They concluded that B6 deficiency could result in burning pain or numbness in the feet, spreading to the legs and the hands.

Vitamin B6 supplements could help improve your nerve health if you have a deficiency.

Alpha-Lipoic Acid (ALA)

Alpha-lipoic acid (ALA) is an antioxidant found in many nerve supplements. Research indicates ALA can alleviate the stabbing and burning pain that many neuropathy patients experience. Sometimes, results may come within just a few weeks.

In a 2006 study, researchers administered varying doses of alpha-lipoic acid. Participants received 600, 1200, or 1800 mg of ALA daily. After five weeks, all three dosages proved more effective than a placebo, though the higher doses resulted in more side effects.

The same study concluded that 300 mg of ALA increased blood flow and reduced inflammation. Both of these effects could help reduce neuropathy symptoms.


Magnesium may also contribute to easing neuropathy pain. The Foundation for Peripheral Neuropathy reports this mineral has shown promise with chemotherapy-related nerve dysfunction. However, they indicated that additional research would be necessary to confirm this connection.

A study published in Nutrients found that chemotherapy patients with higher magnesium levels had fewer neuropathy symptoms. These results suggest the mineral impacts nerve function. However, another study conducted in 2013 found no relationship between magnesium levels and nerve health.


Glutamine is the amino acid found in the highest concentrations in the human body. Research shows it may help with some types of neuropathy, specifically targeting muscle pain, inflammation, tingling, and numbness. One review concluded that it reduced or eliminated nerve pain in chemotherapy patients.

You can get glutamine by eating peanuts, soybeans, wheat, egg whites, and corn. It’s also found in milk products. If you find you aren’t taking in enough of this amino acid, you might benefit from a supplement that contains it.


Glutathione is an antioxidant common to many of today’s nerve supplements. While little research is available, preliminary studies show this substance helps with multiple types of neuropathy, including those caused by:

  • Diabetes
  • Chemotherapy
  • Other health conditions

One drawback to glutathione in supplement form is that it’s hard to get your body to absorb the antioxidant. In most cases, the body breaks it down before it’s absorbed. To resolve this problem, researchers might need to develop a more effective delivery method.

Diet and Lifestyle

Research indicates that specific lifestyle changes can help improve neuropathy symptoms. These include:

  • Controlling blood glucose levels
  • Doing physical exercise
  • Getting a shingles vaccine
  • Reducing inflammation
  • Quitting smoking

When you quit smoking, you contribute to improved blood flow. Any change that increases circulation or reduces inflammation may help ease neuropathy symptoms.

Other Treatments

Most of the suggestions we’ve given so far don’t depend on a doctor’s authorization. However, if you have neuropathy, you need to stay in close contact with your physician. They can help you manage the condition and prevent it from getting worse.

In some severe cases, neuropathy supplements alone may not bring relief. You might need to ask your doctor about additional treatments that may be available.

FAQs About Neuropathy Supplements

Q: What is neuropathy?

A: Neuropathy is a chronic health condition. It occurs when peripheral nerves (those outside the brain and spinal cord) experience damage or compression.

Q: What symptoms does neuropathy cause?

A: Neuropathy often causes pain, numbness, weakness, burning, and tingling in the feet and hands. Some patients have these sensations farther up the legs or arms. Sufferers often describe it as feeling like pins and needles.

Q: What neuropathy treatments might my doctor suggest?

A: The answer to this question depends on the type and severity of your condition. Some physicians may prescribe physical therapy and pain medication. Others might recommend laser therapy or topical formulas.

Medical treatments often target neuropathy symptoms without addressing their source. On the other hand, nerve supplement manufacturers tend to advertise their products as providing long-term support that addresses the root cause of the problem.

Q: What is peripheral neuropathy?

A: Peripheral neuropathy is another term for neuropathy. There’s no difference between the two.

Q: What causes neuropathy?

A: When nerves are damaged or destroyed, peripheral neuropathy results. Your nerves act as pathways through which your brain communicates with the rest of the body. When these channels are damaged or destroyed, your brain receives confusing signals, and you may feel pain, tingling, or numbness.

Q: What are mononeuropathy and polyneuropathy?

A: The prefix “mono” means “one,” and “poly” means “many.” Thus, mononeuropathy affects only one nerve, while polyneuropathy involves damage to multiple nerves.

Q: Why does neuropathy cause varying symptoms in different individuals?

A: Like most nerve conditions, neuropathy is complex and affects people differently. Symptoms depend on how and where the neural pathways have been damaged. There are three main types of nerve disruptions associated with neuropathy:

  • Signal loss – This occurs when messages can’t get through, as in a broken telephone wire.
  • Signal distortion – The messages get altered before they reach the brain.
  • Inappropriate signaling – Messages get sent when they shouldn’t, producing an effect like static on a telephone line.

Q: My doctor mentioned neuropathy surgery. What’s involved with that?

A: Some people may benefit from neuropathy surgery, also called nerve decompression. This procedure occurs in an outpatient setting and involves releasing compression points that may be causing your nerve issues.

Q: What nerves does neuropathy affect?

A: Neuropathy affects three main nerve types. These include:

  • Sensory nerves, responsible for transmitting information like temperature, pressure, and pain throughout the body
  • Motor nerves, which control conscious muscle movement (such as those involved in talking and walking)
  • Autonomic nerves, which control activities that occur automatically within your body (like your heartbeat and breathing)

Q: Does neuropathy cause severe pain?

A: Neuropathy can cause many sensations, from mild discomfort to extreme pain. It all depends on the severity of your nerve damage.

Q: How do medical professionals diagnose neuropathy?

A: This condition can be challenging to diagnose. Symptoms and their severity vary from patient to patient. Even just one person can experience differing degrees of neuropathy over time.

Doctors consider a patient’s medical history as a starting point for a diagnosis. They also rely on results of tests like:

  • Physical and neurological exams
  • Blood and urine tests
  • Genetic tests (if there’s reason to believe there’s a hereditary element)
  • Nerve conduction velocity (NCV) tests
  • Nerve biopsies
  • Electromyography (EMG) tests
  • Neurodiagnostic skin biopsies

Q: What typically causes peripheral neuropathy?

A: As mentioned earlier, this condition results from nerve damage. However, there are several ways this can occur. Some of the most common causes of neuropathy are:

  • Physical injury
  • Diabetes
  • Repetitive movements
  • Smoking
  • Vascular problems
  • Autoimmune disorders and diseases
  • Hormonal imbalances
  • Infections
  • Certain types of cancer
  • Chemotherapy

Physical injury is a widespread cause of neuropathy. For example, a fall, accident, or sports injury can lead to nerve damage. Broken or dislocated bones can also trigger nerve dysfunction.

In the United States, diabetes is the leading cause of neuropathy and over 60% of people with diabetes report some symptoms of nerve damage. The longer you have this disease, the higher your chances of developing neuropathy.

You may have heard of repetitive motion injuries. They occur when the repeated movements of everyday life and work take a toll on muscles, nerves, tendons, and ligaments. Carpal tunnel syndrome is a kind of neuropathy that occurs in the wrist and forearm.

Vascular issues involve your veins, arteries, and capillaries. Problems with blood circulation deprive peripheral nerves of oxygen, damaging them.

Smoking can increase your chances of developing neuropathy. That’s the case because it narrows blood vessels and contributes to high blood pressure. Consequently, quitting smoking may help resolve neuropathy issues.

Q: Is neuropathy preventable?

A: In many cases, the condition is linked to lifestyle choices, so it’s preventable. This is true for most people with diabetic neuropathy.

Diabetes is the leading cause of neuropathy in the U.S., and it’s preventable in most cases. Something as simple as losing weight may stop nerve discomfort for many people. Your doctor can help you find strategies for counteracting neuropathy.

Q: Can prediabetes lead to neuropathy?

A: We’ve clarified that diabetes often leads to nerve dysfunction. That said, nerve disorders can occur in pre-diabetics, too. If your blood glucose levels are above normal, you may be at risk of developing neuropathy.

Q: How do neuropathy supplements work?

A: Not all supplements work the same way. Some improve circulation and reduce inflammation to help you treat the cause of neuropathy. Others provide essential amino acids, vitamins, or minerals that help your body heal itself.

Q: Is neuropathy a genetic condition?

A: In general, neuropathy is more strongly linked to lifestyle factors than genetics. However, there’s at least one type that’s considered hereditary. It’s called Charcot-Marie-Tooth disease.

Q: How can I choose the best neuropathy supplement?

A: The ranking provided at the beginning of this article includes many effective options. By reading the descriptions carefully, you can select the one that best meets your needs. Since most of them include a satisfaction guarantee, you have the option of trying multiple formulas if the first one doesn’t work for you.

The Best Nerve Health Supplements for Neuropathy Conclusion

Neuropathy can be a debilitating condition, causing pain, tingling, numbness, and reduced muscle control. Supplements offer support for healthier nerve function.

Millions of people around the world suffer from neuropathy and long for relief. Choose one of these top-ranked supplements today to help your body heal from nerve dysfunction.

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